[en] Labelled organic compounds have been widely and diligently applied to research problems in life science and chemistry. In many laboratories they have lost their novelty and have been become conventional research tools since long time ago. these applications frequently require organic compounds substituted (or labelled) with isotopes, but the isotopes are (with certain exception) extracted in first place in simple inorganic forms. The conversion of these simple form into the more or less complex labelled compounds called for by research workers has become in effect a new branch of practical organic chemistry. The preparation of labelled compounds, carbon-14 is probably more extensively and variously used than any other isotope. It emits only beta-particles. In this project, two kinds of nucleoside bases under the name uracil-2-¹⁴ C and thymine (methyl-¹⁴ C) were prepared.(author). 14 refs., 3 figs., 2 tabs

[en] N-(3,5-Dichlorobenzyl)-4-(fluoromethoxy) benzenecarboximidamide labeled with carbon-14 was prepared from 4-hydroxy-benzonitrile-[cyano-¹⁴C]. (author)

[en] Two 1,2,3-triazole anticonvulsants, 1-(4-methylsulfone-phenyl)-5-(4-fluoro-phenyl)-5-[¹⁴C]-1,2,3-triazole and 1-(4-sulfonamide-phenyl)-5-(4- fluoro-phenyl)-5-[¹⁴C]-1,2,3-triazole, both labeled with carbon-14 in the 5-position were prepared from para-fluoro-benzonitrile-[cyano-¹⁴C]. (author)

[en] Labelled organic compounds have been widely applied to solve the research problems in life, science and chemistry. The preparation of labelled compounds, with carbon-14 and tritium-3 are probably more extensively and variously used in compare with any other isotopes. These isotopes emit only beta-particle. In this paper the synthesis of DL[³H] Leucine which was prepared for the first time in Iran is described. This compound is used for diagnosis of talasemi disease. The synthetic pathway is achieved by using the condensation of methyl ally chloride with diethyl acetamido malonate in the presence of sodium ethoxid in ethanol. In the next step of the synthesis, the latter compound was hydrogenated with ³H₂(g) over the Adams catalyst in chloroform, which was produced ethyl 2-acetamido-2-carbethoxy-4-methyl pentanoate with a yield of 100%. In final step, the resulted product was converted directly to [4,5-³H] Leucine with the specific activity 5 Ci/mmol, by reflaxing with the hydrobromic acid of 48%

[en] Three 1,2-diaryl pyrroles selective COX-2 inhibitors, 2-(4-fluorophenyl)-5-methyl-1-(4-methylsulfonyl-phenyl)-1H pyrrole, 2-(4-fluorophenyl)-1- [4-(methylsulfonyl) phenyl]-1H-pyrrole and 4-[2-(4-fluorophenyl)-1H-pyrrol-1-yl]benzenesulfon-amide, all three labeled with ¹⁴C in the 2-position were prepared from para-fluoro-benzaldehyde-[carbonyl-¹⁴C]. (author)

[en] There is a mutual protection when mixtures of components irradiated together, so experimental investigation is necessary for determination of the effects that actually occur in different class of nutrients in formulated foods. This work is concerned with the effect of γ irradiated on fatty acids content of a formulated baby food fat and the results is compared with changes of fatty acids in irradiated whole foods. Irradiation was performed with a gamma cell (Co-60) at dose levels of 0.5, 1.5, 6, 10, 30, 45 kGy at room temperature and in the presence of air. The samples were analyzed immediately after irradiation by high performance liquid chromatography. The results showed that destruction of fatty acids in this formulated food is reasonably less than fatty acids of whole foods fat

[en] One of the important herbicide, that can be used for the practical mechanism investigations and studies of metabolism functions of different plants is 2,4 dichlorophenoxy acetic acid compound. In this article, the production method for labeling the titled compound is explained. At the first stage of this research work, barium[¹⁴C] carbonate is converted into potassium [¹⁴C] by using potassium azid at a reasonable temperature. Then, after a few synthesis reaction, the compound 2,4 dichlorophenoxy methyl iodide is produced via 2,4 dichlorophenoxy as a starting material. At the next stage, the real material as a herbicide: 2,4 dichlorophenoxy acetic acid [carboxy- ¹⁴C] is prepared and produced, by the coupling reaction between 2,4 dichlorophenoxy methyl iodide and potassium [¹⁴C] cyanide, and then the resulting nitrile has been hydrolyzed