[en] Bone formation in the autogenous periosteum of the tibia grafted to the floor of the mouth to bridge the mandible was studied by micro-CT to assess its efficacy in evaluating bone formation in rabbits. On soft radiographs, bone formation was observed from both ends of the periosteum on day 14. The bone increased in width and extended medially; contact was made in the center on day 28. The time course of the development of bone trabeculae was well demonstrated three-dimensionally on micro-CT. Indices of bone quality such as Tb-Th, Tb.N, and BV, which reflect the growth of trabeculae, increased gradually from days 14 to 21 and more rapidly from days 21 to 28, whereas Tb. S decreased gradually after grafting. The results suggest that micro-CT is useful in evaluating bone formation three-dimensionally. (author)

[en] Fourteen patients with tongue squamous cell carcinoma were treated with high-dose-rate interstitial brachytherapy. The patients consisted of nine males and five females aged from 40 to 88 years (median age, 71.0 years). As an initial treatment, external radiotherapy was combined for three patients, and intra-arterial chemotherapy was combined for eleven patients. Five-year local control rates were 92.9%. Local recurrence and delayed neck lymph nodes metastasis were detected in two cases (14.3%) and three cases (21.4%) respectively, but all patients lived in non-cancer bearing now, except the one who died from the other illness. The major adverse events were oral mucositis, xerostomia and bone exposure with ulcer. Especially oral mucositis was found in all case, and bone exposure and xerostomia often occurred as late complication. Our date suggested that high-dose-rate brachytherapy for tongue cancer patient may be an effective and an acceptable therapy as a functional preservation therapy against oral cancer. However, this therapy may have a risk of occurrence of radiation osteonecrosis. Thus, we must follow the patient closely. (author)