No abstract available

[en] The production of sterile freeze-dried radiopharmaceutical kits for technetium-99m is carried out at Nuclear Energy Unit. Several factors are considered; availability of suitable kit formulation, sterile stations and sterile items, freeze-drier, and trained personnel and supporting staff. (A.J.)

No abstract available

[en] Radioisotopes are produced by using a low power research reactor, TRIGA MARK II situated at UTN. Products intended for use as radiopharmaceuticals undergo a more stringent precaution. The solvent extraction technique used to separate 99^mTC from the radioactive solution of Potassium molybdate (K₂⁹⁹Mo0₄) is explained in detail. The specific activity of 99Mo obtained at a neutron flux of 2.5 x 10¹² n/cm², s ranges from 1.75 mCi⁹⁹Mo/g MoO₃ to 6.25 mCi ⁹⁹Mo/g MoO₃. However, the specific activity of ⁹⁹Mo obtained could be increased by a factor of 6 using the central thimble facility. There are 14 radioisotopes being currently produced. Commonly used cold kits for ^99mTC labelling are also produced. Sn-MDP kit for bone scintigraphy is prepared under aseptic environment and freeze-drived. Products are terminally sterilized using γ-irradiation. Uptake studies done on laboratory animals indicate good bone uptake. A few radioisotopes and radiopharmaceuticals products to be produced by UTN in future are reviewed. (author)