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[en] The compartmental analysis of biological system is dealt with on several chapters devoted successively to: terminology; a mathematical and symbolic account of a system at equilibrium; different compartment systems; analysis of the experimental results. For this it is pointed out that the application of compartmental systems to biological phenomena is not always without danger. Sometimes the compartmental system established in a reference subject fails to conform in the patient. The compartments can divide into two or join together, completely changing the aspect of the system so that parameters calculated with the old model become entirely false. The conclusion is that the setting up of a compartmental system to represent a biological phenomenon is a tricky undertaking and the results must be constantly criticized and questioned
[fr]
On a traite de l'analyse compartimentale des systemes biologiques en quelques chapitres consacres successivement: a la terminologie; a un rappel mathematique et symbolique d'un systeme en etat d'equilibre; aux differents systemes compartimentaux; enfin a une analyse des resultats experimentaux. A cet effet, on a precise que l'application de systemes compartimentaux aux phenomenes biologiques n'est pas toujours sans danger. Il arrive que le systeme compartimental etabli chez un sujet temoin vienne en defaut chez le patient. Les compartiments peuvent se dedoubler, s'unifier, donnant au systeme un visage totalement different, les parametres calcules avec l'ancien modele devenant totalement faux. On en conclut que la mise en place d'un systeme compartimental pour representer un phenomene biologique est une entreprise delicate dont il faut a tout moment critiquer et remettre en question les resultatsSource
Meyniel, G.; Berger, J.-A.; Chanteur, J.; Cohen, Y.; Di Paola, R.; Ducassou, D.; Gaillard, G.; Isabelle, D.; Lahneche, B.; Martin, J.; Maziere, B.; Moretti, J.-L.; Rosselin, G; p. 158-172; ISBN 2257102339; 
; 1975; Flammarion Medecine Sciences; Paris, France
; 1975; Flammarion Medecine Sciences; Paris, France
[en] Perfusion tracers for brain SPECT imaging suitable for regional cerebral blood flow measurement and regional cerebral blood volume determination, with respect to their ability to pass the blood-brain-barrier, are described. Problems related t the use of specific radiotracers to map receptors distribution in the brain are also discussed in this lecture. 9 figs, 6 tabs
Journal
[en] This lecture is concerned with the use of DMSA 99mTc in nephrology. It described human pharmaceutic and clinical applications of this radiopharmaceutical. As DMSA 99mTc concentrates actively in the proximal convoluted tubule, it gives an image of functional renal mass. Its integrity is dependent upon several factors, predominantly intrarenal blood flow and intact enzyme function. Its role in pathology is clear in pyelonephritis, hydronephrotic kidney and pediatric diseases. The irradiation dosimetry of DMSA 99mTc is well established, the critical organ is the renal cortex which receives between 15 and 250 mGy per MBq. Dosimetry remains favourable for the patients if compared with intravenous urography
Journal
[en] This book presents the technology and the performance of the 18 fluorodeoxyglucose positron tomography in cancer research. The interests, the radiotherapy fields and the therapeutic monitoring are presented. It illustrates the efficiency of the couple TEP-tomodensitometry in the detection of neoplasms. Other tracers are introduced. (A.L.B.)
Source
2004; 181 p; Springer; Paris (France); ISBN 2-287-59771-9;
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