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[en] Besides MS there are a lot of diseases with lesions of the white matter, especially vascular diseases. In quest of a specific pattern in MRI of MS especially in early diagnosis the corpus callosum in patients with MS and in other diseases was analyzed. The progressive atrophy of the corpus callosum in the course of multiple sclerosis is well known. A good correlation between atrophy of the corpus callosum in T1 weighted MRI and the severity of organic mental disorder has been demonstrated. Since Atrophy however is an unspecific sign while demyelinating lesions are much more specific for MS, a brain region in which vascular lesions are rare but demyelinating lesions are more frequent, has been studied. (author). 10 refs.; 2 figs.; 1 tab
Source
Wiethoelter, Horst; Dichgans, Johannes (University of Tuebingen (Germany). Neurological Clinic); Mertin, Juergen (Allensbach (Germany)) (eds.); International Congress Series; no. 960; 404 p; ISBN 0 444 81416 7; 
; 1991; p. 31-36; Excerpta Medica; Amsterdam (Netherlands); 6. Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS); Tuebingen (Germany, F.R.); 11-13 Oct 1990
; 1991; p. 31-36; Excerpta Medica; Amsterdam (Netherlands); 6. Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS); Tuebingen (Germany, F.R.); 11-13 Oct 1990