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AbstractAbstract
[en] The cause of malignant involvement of the sternum is thought to be hematogenous seeding as well as direct invasion from parasternal lymph node metastasis. The purpose of this study was to examine the pattern of metastasis to the sternum in patients with breast cancer and to evaluate the usefulness of postoperative irradiation for controlling sternal metastasis. Of 306 consecutive cases that were retrospectively reviewed, 16 (5.2%) were found to have sternal metastasis. Six cases had only the sternal lesion as the initial site of bone metastasis, and the others had a sternal lesion as part of multiple metastases. Three of 5 cases with a solitary sternal lesion were found by follow-up bone scintigraphy to have expanded to multiple bone metastases. The incidence of sternal metastases in patients with postoperative irradiation was significantly lower than that in nonirradiated patients (p<0.001). Although the incidence of sternal involvement in patients with breast cancer was not low, it might be diminished by postoperative irradiation. (author)
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[en] To determine the availability and limitations of the detection of ischemic lesions by stress thallium-201 myocardial SPECT as the daily routine procedure, we compared and evaluated the detectability of the quantitative analysis (%uptake and washout rate (WR)) and visual evaluation in 104 patients with effort angina and 17 normal subjects. Visual evaluation combined with WR analysis resulted in significantly higher sensitivity (88.0%) but lower specificity (60.2%) than the other methods. The sensitivity by visual evaluation was quite low in multivessel disease (MVD), and in the regions supplied by mild coronary stenosis or by the left circumflex artery. These were markedly improved by combining visual evaluation and WR analysis, but sensitivity in the MVD group was unsatisfactory even with this analytic method in comparison with the single vessel disease group. One of the causes of low sensitivity in the MVD group might be the 'true negative': No induction of the ischemia in the regions of milder stenosis, or the regions supplied by the collateral coronary flow. We therefore conclude that the combination of visual evaluation as a qualitative analysis and WR analysis as a quantitative analysis, is the most useful daily routine procedure as a screening test for detecting ischemia. (author)
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ANEMIAS, ARTERIES, BETA DECAY RADIOISOTOPES, BLOOD VESSELS, BODY, CARDIOVASCULAR DISEASES, CARDIOVASCULAR SYSTEM, COMPUTERIZED TOMOGRAPHY, DAYS LIVING RADIOISOTOPES, DISEASES, ELECTRON CAPTURE RADIOISOTOPES, EMISSION COMPUTED TOMOGRAPHY, HEART, HEAVY NUCLEI, HEMIC DISEASES, ISOTOPES, MUSCLES, NUCLEI, ODD-EVEN NUCLEI, ORGANS, RADIOISOTOPES, SYMPTOMS, THALLIUM ISOTOPES, TOMOGRAPHY
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AbstractAbstract
[en] The gated cardiac pool scan is a means of imaging the blood pool during the cardiac cycle by synchronizing the recording of scintillation data with an electrocardiogram, thus permitting the evaluation of both global and regional ventricular function. Quantification of global ventricular function by the gated cardiac pool scan includes measurement of the left ventricular volume during the cardiac cycle and characterization of the wall motion abnormality of the left ventricle, as is shown in the case of myocardial infarction. The analysis of regional time-activity curve of the gated pool scan permits the regional ejection fraction and regional contraction sequence, as is shown in the case of left bundle branch block. (author)
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Journal Article
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Hai To Shin; ISSN 0440-0852; ; v. 29(2); p. 155-160
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AbstractAbstract
[en] Three-dimensional data processing was developed for single photon computed tomographic imaging of the multigated blood pool with Tc-99m labelled red blood cells. A gamma camera was rotated from the left posterior oblique to the right anterior oblique projections at intervals of 180 deg/32. Data were collected at each part for one to two minutes, and the number of gates per beat was 12 to 20, depending on the patient. Three-dimensional transaxial images of the heart were reconstructed by the filtered back projection method without attenuation correction. A Shepp and Logan filter was used for the convolution filter. Short-axial images were reconstructed from the transaxial images. Using the equicount level method, the contours of both ventricles at each short-axial cross-section image were determined automatically with 50 % levels of the maximum counts. Each contour line was smoothed to the fifth order of Fourier function after conversion from (x-y) coordinates to (r-θ) polar coordinates with respect to the center of the area. Each contour line, converted again into (x-y) coordinates, was drawn successively on a color CRT at constant intervals and inclinations in order to display the ventricles three-dimensionally. It is possible to display simultaneously on a CRT the right and left ventricles or two types of cardiac disease. It is also possible to depict superimposed images of end-diastolic and end-systolic ventricles. The length of the long axis at end-systole in the normal case became less than half the length of the one at end-diastole. In the case of inferior infarction, the length of the left ventricular long axis did not change according to contraction, and akinesis at the inferior wall was clearly imaged. In the case of hypertrophic cardiomyopathy, the thickness of the interventricular septum was markedly increased compared to that of the normal. (J.P.N.)
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Journal Article
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BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, BODY, CARDIOVASCULAR DISEASES, CARDIOVASCULAR SYSTEM, COMPUTERIZED TOMOGRAPHY, DISEASES, EMISSION COMPUTED TOMOGRAPHY, HOURS LIVING RADIOISOTOPES, INTERMEDIATE MASS NUCLEI, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, NUCLEI, ODD-EVEN NUCLEI, ORGANS, RADIOISOTOPES, TECHNETIUM ISOTOPES, TOMOGRAPHY, YEARS LIVING RADIOISOTOPES
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AbstractAbstract
[en] Weighted mean survival time was estimated by platelet method (P-M), plasma radioactivity corrected whole blood method (CWB-M) and noncorrected whole blood method (NWB-M). Platelets were labeled with In-111 tropolone. In normal platelet survival group, mean survival time by P-M, CWB-M and NWB-M were 8.68 ± 0.43 (mean ± 1 SD), 8.80 ± 0.37 and 8.94 ± 0.39, respectively. In short survival group, no significant difference in weighted mean survival time was observed among three methods. In some cases, weighted mean survival time by platelet method was shorter than those by whole blood methods due to the scattering of platelet radioactivity caused by handling of the platelets and/or platelet counting. In the case with smaller erythrocytes contamination during In-111 labeling, the whole blood method especially noncorrected one was useful because it enables easy and precise measurement. (author)
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Journal Article
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ANEMIAS, BETA DECAY RADIOISOTOPES, BIOLOGICAL MATERIALS, BLOOD, BLOOD CELLS, BODY FLUIDS, CARDIOVASCULAR DISEASES, COUNTING TECHNIQUES, DAYS LIVING RADIOISOTOPES, DIAGNOSTIC TECHNIQUES, DISEASES, ELECTRON CAPTURE RADIOISOTOPES, INDIUM ISOTOPES, INJECTION, INTAKE, INTERMEDIATE MASS NUCLEI, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, MATERIALS, MINUTES LIVING RADIOISOTOPES, NUCLEI, ODD-EVEN NUCLEI, RADIOISOTOPE SCANNING, RADIOISOTOPES, SYMPTOMS
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AbstractAbstract
[en] An attempt was made to measure In-111 labeled platelet survival time rapidly in a total of 31 patients with thrombopenia or thromboembolism. Mean platelet survival time and maximum platelet recovery were obtained when platelet radioactivity decreased by 10-19% (L-method), by 20-39% (M-method), and by 40-59% (S-method). Using the conventional L-method as standard, mean platelet survival time was classified as normal (8 days or more), slightly shortened (4-7 days), or extremely shortened (less than 4 days). In the normal group, mean platelet survival time obtained by S-method significantly differed from that by L-method, although there was no difference between M- and L-methods. In the other slightly shortened and extremely shortened groups, there was no significant difference in survival time among the three measurement methods. Regarding maximum platelet recovery and measured maximum, there was no difference among the three measurement methods. It appeared that the S-method is feasible when platelet radioactivity decreases by less than 70% on the 2nd day of measurement; and that the M-method is feasible in the other cases. In measuring platelet survival time, it seemed possible to reduce the measurement days by 1-2 days for the normal group, 1-4 days for the slightly shortened group, and 2-4 days for the extremely shortened group. (N.K.)
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Journal Article
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BETA DECAY RADIOISOTOPES, BIOLOGICAL MATERIALS, BLOOD, BLOOD CELLS, BODY FLUIDS, DAYS LIVING RADIOISOTOPES, DISEASES, ELECTRON CAPTURE RADIOISOTOPES, INDIUM ISOTOPES, INTERMEDIATE MASS NUCLEI, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, MATERIALS, MINUTES LIVING RADIOISOTOPES, NUCLEI, ODD-EVEN NUCLEI, RADIOISOTOPES
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AbstractAbstract
[en] Currently available advanced methods of cardiovascular nuclear medicine for the diagnosis of ischemic heart disease were studied. The methods included the multigate method by a large capacity gamma camera-computer (128 KW memory with multilayer disc) system which made it possible to acquire the data of either the first pass study or the equilibrium study in ''image mode''. Analyzed data were displayed on a color CRT using our moving image system (MIS) and dynamic image thus obtained serve to help for the high sensitive observation of the regional wall motion as well as the global function of the ventricles. Myocardial tomography by a 7 pinhole collimator designed by us was also reported. The myocardial tomogram obtained was proven to show more sensitivity than two dimensional myocardial scan by the conventional collimator to detect smaller lesion and the lesions at the inferior or posterior wall of the left ventricle. The cardiovascular nuclear medicine with recent advanced technologies was thought to be sensitive and useful method for the diagnosis of the ventricular performance and the myocardial ischemia. (author)
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Source
Symposium on the present status of cardiovascular nuclear medicine; Nagoya, Japan; 28 Mar 1980
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Journal Article
Literature Type
Conference
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Nippon Junkankigaku-Shi; ISSN 0047-1828; ; v. 45(1); p. 71-78
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AbstractAbstract
[en] Regional cerebral blood flow (rCBF) values obtained by the TLU method with two 123I-IMP SPECT scans and one point arterial blood sampling and rCBF obtained by the ARG method with one 123I-IMP SPECT scan and fixed distribution volume (Vd) values were compared in 17 cases. A case with post ischemic hyperperfusion or luxury perfusion was not observed in our cases. The correlation coefficients between rCBF values and Vd values obtained by the TLU method were 0.49 (p<0.001) in 184 ROI without hypoactive areas on the early image, and 0.61 (p<0.001) in 207 ROI with hypoactive areas, respectively. A high rCBF value with a low Vd value was not observed in any region. Mean Vd value was 44.0±7.0 (mean±SD) in all regions. The correlation coefficients between rCBF values using the TLU method and those using the ARG method with Vd fixed at 44 and 50 were also 0.98. Error of the rCBF value was larger in the region of high rCBF, however, noticeable error of the rCBF value was not observed in the ARG method. The ARG method is more convenient for quantifying rCBF. Venous blood radioactivity at 10 min after 123I-IMP infusion was smaller than arterial blood radioactivity, and the blood activity in the distal vein was larger than that in the proximal vein. The ratio of venous blood activity to arterial blood activity was 0.92±0.04 (mean±SD) at the back of the hand, however, the ratio was a variant in each case. Arterial sampling was thought to be a reliable method to obtain more stable and precise rCBF. (author)
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BETA DECAY RADIOISOTOPES, BLOOD VESSELS, BODY, BRAIN, CARDIOVASCULAR SYSTEM, CENTRAL NERVOUS SYSTEM, COMPUTERIZED TOMOGRAPHY, ELECTRON CAPTURE RADIOISOTOPES, EMISSION COMPUTED TOMOGRAPHY, HOURS LIVING RADIOISOTOPES, INTERMEDIATE MASS NUCLEI, IODINE ISOTOPES, ISOTOPES, NERVOUS SYSTEM, NUCLEI, ODD-EVEN NUCLEI, ORGANS, RADIOISOTOPES, TOMOGRAPHY
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AbstractAbstract
[en] Published in summary form only
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BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, BIOLOGY, BODY, CARDIOVASCULAR SYSTEM, COMPUTERIZED TOMOGRAPHY, DAYS LIVING RADIOISOTOPES, ELECTRON CAPTURE RADIOISOTOPES, EMISSION COMPUTED TOMOGRAPHY, HEART, HEAVY NUCLEI, HOURS LIVING RADIOISOTOPES, INTERMEDIATE MASS NUCLEI, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, MOCKUP, MUSCLES, NUCLEI, ODD-EVEN NUCLEI, RADIOISOTOPES, SIMULATION, STRUCTURAL MODELS, TECHNETIUM ISOTOPES, THALLIUM ISOTOPES, TOMOGRAPHY, YEARS LIVING RADIOISOTOPES
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AbstractAbstract
[en] This study was undertaken to evaluate 99mTc-DTPA renography before and after extracorporeal shock wave lithotripsy (ESWL). Twelve patients with renal calculi were examined in this study. In three patients, bilateral kidneys were treated with ESWL. Sequential renal images of the vascular phase, and the functional and excretory phases were taken using a gamma camera (ZLC 7500, Siemens), after intravenous injection of 555 MBq of 99mTc-DTPA. Renograms were generated using data stored every 10 seconds for a period of 30 minutes by computer (Scintipac-2400, Shimadzu). Some treated kidneys were enlarged and/or showed uniform retention of radioactivity on sequential images, within a week after ESWL. Renogram patterns after ESWL were varied in each patient. The renogram findings after ESWL seemed to be affected by the presence or absence of stone fragments in the urinary tract. (author)
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AMINO ACIDS, BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, BODY, CARBOXYLIC ACIDS, CHELATING AGENTS, CLEARANCE, COUNTING TECHNIQUES, DIAGNOSTIC TECHNIQUES, DRUGS, EXCRETION, HOURS LIVING RADIOISOTOPES, INTERMEDIATE MASS NUCLEI, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, MEDICINE, NUCLEI, ODD-EVEN NUCLEI, ORGANIC ACIDS, ORGANIC COMPOUNDS, ORGANS, RADIOISOTOPES, RADIOPROTECTIVE SUBSTANCES, RESPONSE MODIFYING FACTORS, TECHNETIUM ISOTOPES, YEARS LIVING RADIOISOTOPES
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