[en] The capacity of superoxide anion production of polymorphonuclear leukocytes (PMNL) has been determined after whole body irradiation. A diminished capacity of superoxide anion production in the presence of opsonized zymosan was found in PMNL taken from guinea pigs irradiated in vivo with 5, 10, and 20 Gy. However, no such diminution was found after a dose of 2 Gy. On the other hand, levels of superoxide anion production stimulated by myristate, N-Formyl-Methionyl-Leucyl-Phenylalanine (FMLP), and Concanavalin A remained unchanged compared to the control. PMNL irradiated in vitro with 20 Gy had a capacity of superoxide anion production similar to that of the control samples in the presence of either opsonized zymosan or FMLP and myristate. These results suggest that the capacity of superoxide anion production stimulated by zymosan is damaged by whole body irradiation. (author)

[en] A method of superimposing two images obtained by ⁶⁷Ga-SPECT and X-ray CT was applied in 29 cases of abnormal uptake on ⁶⁷ scintigraphy. Abnormal uptake was more clearly displayed by composite SPECT-CT image than by conventional methods. The superimposition of images was useful to obtain both morphological and qualitaive information. (author)

[en] ^99mTc-DTPA-galactosyl human serum albumin (Tc-GSA) is a new liver-imaging agent which binds specifically to hepatic bonding protein. The purpose of this study was to evaluate the usefulness of Tc-GSA in quantitatively evaluating hepatic ischemia-reperfusion injury in the rat. Regional hepatic ischemia was induced by clamping the left hepatic artery and the left portal vein for 5 to 45 min. A hepatic accumulation index (t₉₀) was obtained on the basis of the dynamic data. A significant difference of this index was observed between all ischemic groups and the control. In conclusion, ^99mTc-GSA appears useful for evaluating the hepatic ischemia-reperfusion injury. (author)

[en] Circumferential profile analysis is one of quantitative analyses in ²⁰¹Tl myocardial scintigraphy. We compared the detectability of coronary artery stenosis between 4 various methods of circumferential profiles (peak point method, all points method, 3 points around the peak method and average method) based on short-axial images of ²⁰¹Tl myocardial single photon emission computed tomography. Diagnostic criteria for coronary artery stenosis was that the circumferential profile curve of a patient was below the normal limit (mean -2 SD) obtained from 23 normal volunteers in more than serial 3 profiles. After examining 16 patients with coronary artery stenosis demonstrated by coronary arteriography, it was concluded that both peak point method and 3 points around the peak method surpassed other methods in the delectability of clinically significant coronary artery stenosis. (author)

[en] Accumulation of ^99mTc-MIBI has been reported in several various carcinomas. In this study, ^99mTc-MIBI scintigraphy was evaluated to detect recurrent or metastatic lesion in seven patients with thyroid carcinoma. The results were compared with those of ¹³¹I scintigraphy and ²⁰¹Tl scintigraphy. Bone metastasis and lymphnode metastasis were well demonstrated in ^99mTc-MIBI scintigraphy, but ¹³¹I scintigraphy allows the best visualization of pulmonary metastasis. ^99mTc-MIBI scintigraphy has desirable characteristics including the potential for no thyroid hormone withdrawal, immediate imaging postinjection, and low radiation burden. In conclusion, it is shown that ^99mTc-MIBI scintigraphy is a useful procedure in follow-up of thyroid carcinoma and has the potential for visualization of metastasis when ¹³¹I was negative. (author)

[en] The significance of high renal uptake found in patients with hematological disease who underwent bone marrow scintigraphy with ¹¹¹In-chloride was investigated. In patients with a high renal uptake, the uptake in bone marrow was low, suggesting a reflection of erythropoietic activity. The reversal relationship, however, was not necessarily present. With regard to correlation with iron metabolism, significantly higher uptake of serum Fe and lower UIBC were found among those with high renal uptake, suggesting that the level of free trans ferrin in the serum is largely involved in the high uptake in the kidney. (author)

[en] Bone marrow scintigraphy with indium chloride (¹¹¹In) was performed in fifty-one patients with the hematological diseases. The results of the investigation were that 1) in all patients, as well as in patients with aplastic anemia, no correlation was there between the degree of the indium chloride accumulation and peripheral blood counts, 2) in patients with aplastic anemia and pure red cell aplasia (PRCA) a tendency to reduction in uptake of indium chloride in bone marrow, 3) in patients with these two good correlation between the degree of indium chloride accumulation and histology of the erythroid bone marrow, but in patients with chronic myelocytic leukemia (CML) and atypical leukemia no correlation between the two, so it seemed unlikely that indium chloride should reflect the effective production of erythrocytes, 4) four patients with leukemia were studied with indium chloride bone marrow imaging two times to evaluate their responses to chemotherapy, and peripheral expansion was no change or reduced in two patients with acute myelocytic leukemia (AML) and one patient with acute lymphocytic leukemia (ALL) who obtained complete remission, but on the other hand, it enlarged in one patient with acute myelocytic leukemia who obtained partial remission, and 5) in two patients with chronic myelocytic leukemia it enlarged up to the ankle joints, which was considerably specific. (author)

[en] We evaluated quantitatively the liver injury of rats induced by ischemia-reperfusion, using ^99mTc-DTPA-galactosyl-human-serum-albumin (^99mTc-GSA). The vessels of the left lobe were clamped for 5, 10, or 45 minutes followed by 15 minutes reperfusion. Then, ^99mTc-GSA was intravenously administered (170 μg/kg body weight) to rats. Two compartment analysis was made on measurement curves in the heart and liver to obtain clearance parameters. Significant difference was observed between the ischemic group (clamped for 10 and for 45 minutes) and the control. These results suggest that ^99mTc-GSA is useful in the estimation of liver injury produced by ischemia-reperfusion. (author)

[en] High resolution computed tomography (HRCT) and three dimensional CT (3DCT) were performed in 9 patients with chronic osteomyelitis of the mandible and 2 patients with gingival carcinoma. The periosteal reaction was seen only in the osteomyelitis cases. The irregular destruction of the cortical bone was seen mainly in the malignant cases. The sclerotic change was severer in the osteomyelitis than in the malignant tumor. The extension and the shape of the lesion could be evaluated accurately by HRCT and 3DCT and the soft-tissue changes were also revealed clearly by the soft-tissue mode of the HRCT. (author)

[en] Computed tomography (CT) findings were assessed in 7 patients with malignant mesothelioma. CT findings were also reviewed in 9 patients with lung cancer and pleuritis carcinomatosa and in 11 patients with tuberculous pleuritis. Five patients with malignant mesothelioma underwent CT scans twice, on admission and from 1 to 7 months after admission. Tuberculous pleuritis could be distinguished from pleuritis carcinomatosa and malignant mesothelioma by the presence or absence of pleural nodularity and chest wall invasion. Although it was difficult to identify specific CT features clearly distinguishing malignant mesothelioma from pleuritis carcinomatosa, characteristic findings of malignant mesothelioma appeared to include the rapid development and progression of pleural rind and a tendency to spread directly into the chest wall. We divided the pleural into the four regions; upper anterior, upper posterior, lower anterior and lower posterior regions. Pleural changes were more frequently seen in the lower pleural regions than in the upper pleural regions in malignant mesothelioma. (author)