[en] Short communication

[en] FDT-PET imaging has become a major tool in the management of cancer patients including head and neck tumors. It is extremely useful for detecting unknown primary tumors or for detecting an additional primary tumor. It can help guiding biopsies of equivocal lesions located in regions that cannot easily be reached. The impact of PET is more limited for evaluating a known primary tumor. Its role for initial lymph node staging remains unclear, as its rather limited spatial resolution prevents the detection of the smallest nodal metastases, thus limiting the clinical impact. It could be help by picking up contralateral nodal lesions but prospective studies should clarify its real impact in clinically N0 patients. Up to now, the major indication for PET is the detection and staging of recurrences in patients previously treated by surgery and/or irradiation. Its potential for assessing the response to treatment early on after chemotherapy or later on after radiation therapy, as well as its prognostic value, may help the clinician to choose the best therapeutic regimen, in particular in high-risk patients. (author)

[en] Radiosynoviorthesis is used for the local treatment of recurrent joint effusions and leads to synovial pannus necrosis after radionuclide administration. This procedure provides the opportunity to full recovery of normal synovium function after local corticosteroids and systemic modifying drugs failure. (authors)

[en] We have studied 37 patients presenting head or neck cancers: 25 at the moment of initial extension account, prior to any treatment and 12 presenting a confirmed recurrence. The ensemble of palpation, TDM and TEP with ¹⁸FDG data could been correlated with the results of histopathological examination of the operation piece. The initial extension account had the following results: all the primitive tumors got detected in 25 patients, among whose 10 presented an ganglionic invasion, confirmed in the histopathologic examination. The TEP with ¹⁸FDG permitted identifying a counter-lateral ganglion, not evidenced by palpation and structural imaging. We report unfortunately 5 false negatives results (microscopical or of small size lesions) and two false negative examinations. Recurrences were also made evident: 11/12 patients were correctly identified by TEP with ¹⁸FDG. A falsely positive result was related to the presence of a granulomatous reaction on strange body. The TEP with ¹⁸FDG permitted making evident two local recurrences and two other cases of ganglionic invasion, un-detected by other techniques. The clinical utility of TEP with ¹⁸FDG appeared essential in the detection of recurrences in operated and irradiated territories but in a lesser extension in the definition of ganglionic extension account

[en] Positron emission tomography studies organ perfusion and metabolism at the cellular and molecular levels. Its clinical use is now well documented in oncology, cardiology and neurology. This review outlines the principal clinical indications as well as their diagnostic nd therapeutic outcome. (author)

[en] Short communication

[en] Short communication

[en] Short communication

[en] We report the first μSR measurements done on a cluster of monodisperse Pd nanoparticles. The measurements give access to the dipole field from the unpaired electron magnetic moments. We find for a two shell compound that the field is smaller than expected. The moments at the origin of the field are quasi-static, i.e. fluctuate in the microsecond time range

[en] Accurate staging of non-Hodgkin's lymphoma (NHL) is important for treatment management. We studied 53 patients (40 patients at initial diagnosis and 13 patients at disease recurrence) with histopathologically proven aggressive NHL to assess the value of whole-body FDG positron emission tomography (PET) as an imaging modality for staging and re-staging NHL. All patients in this comparative analysis were submitted to clinical examination; computed tomography (CT) and whole-body PET studies before starting the treatment. Results: Whole-body FDG-PET seems to be more sensitive than clinical examination and CT imaging for detection of lymph node regions infiltrated by NHL: there were 98 abnormal peripheral lymph node regions seen by FDG-PET: 59 observed by clinical examination and 39 clinically undetected. The clinic examination showed 9 additional nodal lesions not seen by PET. Of 77 thoracic and abdomino-pelvic lymph node regions demonstrated by FDG-PET, 56 lesions were identified by CT while 21 are not illustrated by CT. The CT studies showed 5 additional nodal lesions. Extra-nodal lymphomatous localizations in the liver (n = 5), spleen (n = 14), lungs (n = 8), pleura (n = 9), digestive tract (n = 4), pelvis (n = 2) and other sites (n = 9) were identified by PET. Bone marrow infiltration demonstrated by PET was confirmed by biopsy in 6/10 patients, however known medullary invasion was not seen by PET imaging in 5 patients. Conclusion: whole-body FDG-PET without attenuation correction is an efficient, non-invasive method for staging and re-staging aggressive NHL but marrow biopsy remains to be performed in addition to PET. (author)