[en] Two wheat varieties were used to investigate the uptake of ¹³⁷Cs from the red soils with different radioactivity in Jangxi province, China. ¹³⁷Cs in all of the wheat plant was detected except the plants in holt soil, in which the radioactivity of ¹³⁷Cs was very low. And the ability of ¹³⁷Cs uptake from soil, expressed with TF, was in order of grass land (116.36) > drought rice soil (47.22) > drought cultivated soil (27.33) > forestry land (nearly to background) with Yang wheat-12, and grass land (194.92) > drought rice soil (16.54) > drought cultivated soil (13.41) > forestry land (nearly to background) with Yang wheat-158. The content of ¹³⁷Cs in different parts of wheat was: roots > stalk and hull > seeds. The ¹³⁷Cs uptake of wheat affects the estimation of soil erosion rates largely. The tow results of soil erosion rates predicted with Y-model in consideration of wheat uptake or not are different widely, from 2661.2kg/(hm² · a) to 10644.8kg/(hm² · a). We can amend quantitative models according to this conclusion. (authors)

[en] Objective: To prepare and label the ¹²⁵I-β-CIT and study its biological distribution in animal. Methods: ¹²⁵I-β-CIT was prepared by the peracetic acid method and the chloramine-T method, and dopamine transporter (DAT) binding properties of ¹²⁵I-β-CIT were examined by in vivo biodistribution and inhibition studies in mice and whole body autoradiography in rats. Results: The radiolabelling yields of the peracetic acid and the chloramine-T methods were (53.4 +- 7.9)% and (88.4 +- 3.49)%, respectively. Following intravenous injection in mice, ¹²⁵I-β-CIT showed high accumulation in striatum, time to peak level uptake was 2 h after injection. GBR12909 significantly inhibited ¹²⁵I-β-CIT binding in striatum, while clomipramine significantly inhibited ¹²⁵I-β-CIT binding in hippocampus and cerebral cortex. The rat whole body autoradiography showed that the clearance of the tracer occurred through the hepatobiliary route. Conclusions: The results indicate β-CIT is an agent suitable for DAT imaging and can be used for the study of Parkinson's disease

[en] Highlights: • STING and ORMDL3 genes expression was increased in patients with recurrent wheeze. • STING upregulates ORMDL3 expression and promoter activity in cells. • ORMDL3 is positively associated with the STING-TBK1-IRF3/STAT6 signaling pathway. • STING increases the ORMDL3 expression in asthma and recurrent wheeze by promoting both the expression and activity of the TBK1-IRF3-STAT6 complex. Orosomucoid 1-like protein 3 (ORMDL3) is an asthma candidate gene associated with virus-triggered recurrent wheeze. Stimulator of interferon gene (STING) controls TLR-independent cytosolic responses to viruses. However, the association of STING with ORMDL3 is unclear. Here, we have shown that ORMDL3 expression shows a linear correlation with STING in recurrent wheeze patients. In elucidating the molecular mechanisms of the ORMDL3-STING relationship, we found that STING promoted the transcriptional activity of ORMDL3, which was significantly associated with increased levels of interferon regulatory factor 3 (IRF3) and signal transducer and activator of transcription 6 (STAT6). Further study showed that via activation of TANK binding kinase 1 (TBK1), STING enhanced the phosphorylation and binding of IRF3 and STAT6, which upregulated ORMDL3 by binding to the promoter. Our results showed that STING positively regulated ORMDL3 through the TBK1-IRF3-STAT6 complex.