No abstract available

[en] The objectives and methods of a case study in Washington State related to liability insurance coverage for the in-state management, transportation, and disposal of low-level radioactive waste (LLW) are presented. Projected results of the case study are reviewed and Washington's case study objectives are compared with federal financial assurance objectives for the activities of concern

[en] N-(3,5-Dichlorophenyl)succinimide (NDPS) is a selective nephrotoxin in rats. Previous studies in the authors' laboratory have demonstrated that a NDPS metabolite of extrarenal origin contributes to NDPS-induced nephrotoxicity. The purpose of this study was to examine the in vitro effects of NDPS on organic ion accumulation by renal cortical slices. Male Fischer 344 rats were killed by cervical dislocation, and kidneys rapidly removed. Renal cortical slices were prepared freehand and incubated (30 min) at 25 or 37⁰C with NDPS (10^-4 to 10^-7M) or vehicle (30 μ1). [¹⁴C]-Tetraethylammonium (TEA) or [¹⁴C]-p-amino-hippurate (PAH) was added and incubations continued for 90 min. At 25⁰C, only basal PAH uptake was reduced by NDPS (10^-4M) while lower NDPS accumulations did not decrease PAH or TEA uptake. At 37⁰C, TEA uptake was decreased at NDPS concentrations of 10^-5M or greater while basal and lactate-stimulated PAH uptake were decreased at a NDPS concentration of 10^-4M. These results suggest that the kidney as well as extrarenal tissues may be capable of forming the nephrotoxic NDPS species