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[en] The results of mixed photo-electron therapy in 85 patients with early glottic cancer are presented. 85% of the patients were in poor general condition. All patients received radiation to a single lateral laryngeal field of 6 X 6 to 8 X 8 cm2 and the dose of 64 Gy to 70 Gy in 6 to 7 weeks. Half of the dose was delivered with a telecobalt unit and half with 15 MeV electrons. 78.8% patients (67/85) survived without evidence of malignancy for three years after the radiation therapy alone, and 5 patients survived after salvage surgery. The overall crude survival rate was 84.7% at three years. Three-year survival rates without evidence of malignancy were 91.5% in stage I and 69.2% in stage II
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[en] On the basis of the literature the clinical picture, treatment and prognosis of the small cell laryngeal cancer has been discussed. The authors presented 2 own cases. After laryngectomy patients were treated with radio- and chemotherapy
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Drobnokomorkowy rak krtani. Analiza pismiennictwa i dwoch wlasnych przypadkow; treated with radiotherapy
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Otolaryngologia Polska; ISSN 0030-6657; ; v. 48(1); p. 83-85
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ANIMALS, BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, COBALT ISOTOPES, DISEASES, INTERMEDIATE MASS NUCLEI, INTERNAL CONVERSION RADIOISOTOPES, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, MAMMALS, MAN, MEDICINE, MINUTES LIVING RADIOISOTOPES, NUCLEI, ODD-ODD NUCLEI, PRIMATES, RADIOISOTOPES, RESPIRATORY SYSTEM, SURGERY, THERAPY, VERTEBRATES, YEARS LIVING RADIOISOTOPES
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[en] This work is a retrospective study of 75 patients with non small cell lung cancer irradiated postoperatively. The overall 5-year survival rate of 28% was achieved. The extent of surgical resection and post-surgical (pathologic-pTNM) staging are two significant prognostic factors. The best results (70% of 5-year survival) was obtained in patients without mediastinal metastases, irradiated for microscopic residual tumour on the resected margin. Postoperative irradiation was ineffective in the group of patients with mediastinal lymph node involvement and with microscopical incomplete surgery
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Radiotherapie postoperatoire des cancers bronchopulmonaires non a petites cellules. A propos de 75 cas
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[en] Presented are the results of treatment of 130 patients with stage 1. testicular seminoma who are managed after orchidectomy by adjuvant radiotherapy. The 5-year survival rate NED in all group was 96.9%; in the group irradiated with dose 30 Gy in 24 fractions in 5 weeks it was 100% without acute toxicities or complications. (author)
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Ocena skutecznosci uzupelniajacej radioterapii chorych na nasieniaka jadra w 1. stopniu zaawansowania
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10 refs, 1 tab.
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[en] Between 1970 and 1985, 130 patients were irradiated with curative intent at the Center of Oncology in Krakow. The histological diagnosis was squamous-cell carcinoma in 60.8% of patients, adenocarcinoma in 25.4% of patients and other non-small cell cancer in 13.8% of patients. All patients were treated with megavoltage radiation. Patients with stage I were treated by three isocentric beams. Tumor dose was 6000 cGy in 24 fractions over five weeks. In patients with stage II and III A disease the radiotherapy was started with two parallel opposed beams encompassing primary lesion and mediastinum. The dose of 4000 cGy was given in 20 fractions over four weeks, followed by a 'boost' dose of 2000 cGy in the fractions over two weeks, delivered with three isocentric beams. 54% of patients were disease-free at the twelfth month, 24.6% at the 36th month, and 18.5% of patients survived five years without evidence of cancer. A significantly better survival has been observed in patients with stages I and II, with Karnofsky performance status ≥70, and with complete radiological regression eight weeks after radiation therapy. The main cause of failure of the treatment were distant metastases. (orig./MG)
[de]
Zwischen 1970 und 1985 wurden 130 Patienten am Onkologischen Zentrum von Krakau in kurativer Absicht bestrahlt. Die histologische Diagnose lautete bei 60,8% der Patienten auf Plattenepithelkarzinom, bei 25,4% der Patienten auf Adenokarzinom und bei 13,8% der Patienten auf sonstige nichtkleinzellige Karzinome. Alle Patienten erhielten eine Bestrahlung im Megavoltbereich. Die Patienten in Stadium I wurden mit drei isozentrischen Strahlen behandelt. Die Tumordosis betrug 6000 cGy in 24 Fraktionen in einem Zeitraum von fuenf Wochen. Bei den Patienten in den Stadien II und III A wurde die Strahlentherapie als parallele Gegenfeldbestrahlung unter Einschluss des Primaertumors und des Mediastinums begonnen. Die Dosis von 4000 cGy wurd in 20 Fraktionen in einem Zeitrum von fuenf Wochen verabreicht. Im Anschluss daran erhielten die Patienten eine Boost-Dosis von 2000 cGy mit drei isozentrischen Strahlen, die in zehn Fraktionen ueber einen Zeitrum von zwei Wochen verabreicht wurden. Nach zwoelf Monaten waren 54%, nach 36 Monaten 24,6% der Patienten tumorfrei, und 18.5% der Patienten ueberlebten fuenf Jahre ohne Krankheitszeichen. Bei Patienten in den Stadien I und II mit einem Karnofsky-Leistungsstatus ≥70 und radiologischer Vollregression acht Wochen nach der Stralentherapie wurde eine signifikant bessere Ueberlebensrate beobachtet. Bei einem Behandlungsmisserfolg lag die Ursache hauptsaechlich im Auftreten von Fernmetastasen. (orig./MG)Primary Subject
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[en] Between 1983 and 1990, 332 patients with non-small cell lung cancer (NSCLC) were referred to short-time, split-course palliative thoracic radiotherapy. The group consisted of patients with locally advanced (IIIo), unresectable cancer, not suitable for curative radiotherapy, asymptomatic or having only minimal symptoms related to intrathoracic tumor. The therapeutic plan involved two series of irradiation. Tumor dose delivered in each series was 20 Gy given in five daily fractions over five treatment days. There were four weeks interval between series. Of 332 patients initially qualified to thoracic radiotherapy only 170 patients received the treatment; the other 162 patients were not irradiated because of treatment refusal or logistic problems concerning therapy. They made the control group of the study, receiving the best possible symptomatic care. Twelve-month survivals in the radiotherapy and control groups were 32.4% and 9.3%, respectively; 24-month survivals 11.2% and 0%, respectively. Improvement of survival after palliative thoracic radiotherapy was observed only in patients with clinical stage IIIA and Karnofsky's performance status (KPS) ≥ 70. (orig.)
[de]
Zwischen 1983 und 1990 wurden 332 Patienten mit nichtkleinzelligem Lungenkrebs einer kurzzeitigen, palliativen Strahlentherapie des Thorax im Split-course-Verfahren unterzogen. Die Gruppe bestand aus Patienten mit lokal fortgeschrittenem (IIIo), nicht resezierbarem Krebs, der fuer eine Strahlentherapie mit kurativer Zielsetzung nicht geeignet war. Die Patienten waren symptomlos oder zeigten nur minimale Symptome eines intrathorakalen Tumors. Der Behandlungsplan enthielt zwei Bestrahlungsserien. Die Tumordosis betrug 20 Gy pro Serie, die ueber einen Zeitraum von fuenf Behandlungstagen in je fuenf Fraktionen verabreicht wurde. Die Pause zwischen den beiden Serien betrug vier Wochen. Nur 170 der 332 urspruenglich fuer die Thoraxbestrahlung qualifizierten Patienten erhielten die Behandlung; die uebrigen 182 Patienten wurden aufgrund von Behandlungsverweigerung oder wegen logistischer Probleme bezueglich der Therapie nicht bestrahlt. Diese bildeten die Kontrollgruppe fuer diese Studie, wobei sie die bestmoegliche symptomatische Behandlung erhielten. Die Zwoelf-Monats-Ueberlebensraten betrugen 32,4% bei der Strahlentherapiegruppe und 9,3% bei der Kontrollgruppe; die 24-Monats-Ueberlebensraten lagen bei 11,2% bzw. 0%. Eine verlaengerte Lebenszeit nach palliativer Thoraxbestrahlung wurde nur bei Patienten im klinischen Stadium IIIA und mit Karnofsky-Status (KPS) ≥ 70 beobachtet. (orig.)Primary Subject
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