[en] Sixty-three patients aged 21-80 yr were examined. Tc-99m glucoheptonate (Tc-GH) scintigraphy was performed in 32 patients: 26 with primary lung carcinoma; six with metastases in lung, mediastinum, and pleura from carcinomas elsewhere; eight with benign pulmonary diseases; and 23 without known pulmonary disease. Tc-GH accumulated in 23 of 26 primary pulmonary carcinomas as active foci. The specificity of Tc-GH scans for neoplasm detection was higher than that of chest radiographs. The visualization of malignant tumors was much better in the late Tc-GH images (5-6 hr) than in the early (1 hr). Metastases from other carcinomas were positive in four of six patients, but they were considerably better detected in the radiographs, except in one patient with metastatic hepatocellular carcinoma. Neoplasms or their metastases in the hilar and mediastinal regions were better detected in the Tc-GH scans than in the chest radiographs. Only one of eight benign lung processes was visualized (as a weak diffuse accumulation of Tc-GH in hilar scar formation), and 23 patients without pulmonary disease had no pathological foci

No abstract available

[en] A new use of Tc-99m glucoheptonate (GH) in detection of the nature of decreased uptake in liver colloid scintigraphy is described. 47 defects in liver scintigraphies of 27 patients with malignant liver processes accumulated almost similarly GH as the surrounding liver tissue or even more, whereas 10 defects of 5 patients with benign liver diseases did not accumulate GH markedly. GH seems to be very promising in detection of malignant liver processes

[en] The optimum conditions for labelling platelets with lipophilic ^99mTc-hexamethyl propylene amine oxime (^99mTc-HMPAO) were evaluated. An aseptic closed system was used throughout the procedure in patient studies. 48 ml blood were withdrawn into 12 ml ACD using sterile 60 ml plastic syringes. After mixing, the blood was transferred to sterile 10 ml vacuum tubes and platelets were isolated according to standard centrifugation procedures. The labelling efficiency was not dependent upon incubation temperature (22 deg. C, 37 deg. C) but was greater in saline than in the presence of plasma. The labelling efficiency increased with time up to 60 min in saline. The elution of ^99mTc from platelets was about 25% in plasma milieu in vitro but did not increase with time during 160 min. 5 patients with verified fresh deep vein thrombosis in the lower leg were imaged after injection of labelled autologous platelets. All 4 of the patients without anticoagulant therapy showed positive uptake of ^99mTc-HMPAO-labelled platelets, but the 5th patient - under heparin therapy - was negative in scientigraphy. Our results are encouraging and ^99mTc-HMPAO-labelled platelets offer a promising tool for evaluating various clinical situations. (author)

[en] A case of a squamous cell lung carcinoma detected with sup(99m)Tc-DPD, ⁶⁷Ga-citrate and sup(99m)Tc-glucoheptonate (GH) is reported. The highest uptake was seen with DPD and the lowest with ⁶⁷Ga. Emission-computed tomography was very useful in DPD imaging but gave less new information in GH and ⁶⁷Ga studies in comparison to traditional planar imaging. The patient had been given both irradiation and chemotherapy, which might be the cause of good accumulation of DPD and rather poor accumulation of GH and ⁶⁷Ga. (orig.)

[en] Sixty-five patients with suspected or proven pulmonary malignancy were examined with [⁶⁷Ga]citrate and [/sup 99m/Tc]glucoheptonate ([/sup 99m/Tc]GH) scintigraphy. In the final diagnosis 39 had primary lung carcinoma, four metastases in lung, mediastinum, and pleura from carcinomas elsewhere, and 22 benign pulmonary diseases. The sensitivity in the detection of pulmonary malignancies was 91% with ⁶⁷Ga and 95% with [/sup 99m/Tc]GH. The intensity of uptake was somewhat greater with ⁶⁷Ga than with [/sup 99m/Tc]GH in almost all malignant lung tumor groups. The specificity to detect malignant tumors was 82% with both radiopharmaceuticals. Irradiation and chemotherapy seemed to decrease ⁶⁷Ga uptake but not [/sup 99m/Tc]GH uptake. Only four of 22 benign diseases showed accumulation of both ⁶⁷Ga and [/sup 99m/Tc]GH. The intensity of uptake in benign processes was almost equal with that in malignant diseases, but most malignant processes were better delineated than the benign lesions. There were many differences between ⁶⁷Ga and [/sup 99m/Tc]GH uptake, which suggest different mechanisms of accumulation of these agents. It is concluded that some ⁶⁷Ga studies could be replaced by cheaper and more practical [/sup 99m/Tc]GH