[en] This study aims to investigate the relationship between the determination of dopamine level by high performance liquid chromatography (HPLC) with electrochemical detection (ECD) and the detection of dopamine transporter (DAT) counts using autoradiography with DAT image agent [^99mTc]TRODAT-1. For striatal lesions, pretreatment of 6-hydroxydopamine (6-OHDA) in the medial forebrain bundle shows that autoradiogaphic labeling of striatum region is reduced to near-background level. Using HPLC with ECD, unilateral 6-OHDA treatment is associated with significant (p<0.0002) reductions of dopamine levels. For the striatum of the 6-OHDA-lesioned side, dopamine content and DAT counts are reduced to 97% and 90%, respectively. Thus, our observation indicates a potential of using [^99mTc]TRODAT-1 for the evaluation of animal DAT

[en] A quantitative model for the size-dependent Young’s modulus Y(D) of nanomaterials is established in this work by considering the modulus of single bond and bond number in nanomaterials. Due to bond relaxation, the single bond strength and it’s elastic modulus are enhanced as size drops, while bond number is decreased. This makes the Young’s moduli of nanomaterials possess different change with size. If compared with bulk Young’s modulus Y₀, both the stiffer with Y(D) > Y₀ and the softer with Y(D) < Y₀ for different nanomaterials are predicted. The corresponding experimental or simulation results show their good consistence with the model predictions, which greatly confirms the reasonability of the established model. (paper)

[en] ZnO thin films deposited on fused silica glass substrates were sequentially implanted with P ions in terms of different energy/fluence combinations, i.e. 150 keV/1.5 × 10¹⁵ ions cm⁻², 80 keV/5.5 × 10¹⁴ ions cm⁻² and 35 keV/2.5 × 10¹⁴ ions cm⁻², or were singly implanted with 150 keV P ions at a fluence of 1.5 × 10¹⁵ ions cm⁻². X-ray diffraction, photoluminescence, Hall effect and electrical resistivity measurements were performed to characterize the properties of the films. The results show that both the unimplanted and single-P-ion-implanted films exhibit semi-insulating properties, while the sequentially implanted film shows p-type conductivity with a low carrier concentration. After annealing at 500 °C, hole concentration increases distinctly in the sequentially implanted film, and the other films show n-type conductivity. Further increasing annealing temperature to 700 °C, all the films show large resistance. Moreover, structures and optical properties of these films have also been systematically investigated. It seems that P substitutes O (P_O) and/or zinc vacancies (V_Zn) play an important role for p-type conductivity in sequentially implanted films