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AbstractAbstract
[en] The purpose of the presented work is to synthesize 99Tcm-labeled dopamin D2 receptor imaging agent 2-{1-[(1-Ethoxycarbonyl-2-mercapto-ethylamino)-methyl]}-3-{4-[(1-ethyl pyrrolidin-2-ylmethyl)-carbamoyl] -3-methoxy-5-bromo-phenylamino}-propylamino)-3-mercapto-propionic acid ethyl ester (99Tcm-m-Br-p-EBZM). The ECD was coupled with the benzamide derivative, N-[(1-ethyl-2-pyrrolidinealkyl)methyl]-4-acetylamino-5-bromium-2- methyloxygen-= benzol formamide, to yield m-Br-p-EBZM. The labeling compound was prepared through two steps of exchange labeling with 99Tcm-glucohetonate, and its stability was observed. Results show that m-Br-p-EBZM was synthesized for the first time, and was successfully labeled with 99Tcm with 98% of radiochemical purity, high stability and good liposolubility,. Hence 99Tcm-m-Br-p-EBZM may become a potential dopamine D2 receptor imaging agent. (authors)
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Source
1 fig., 7 refs.
Record Type
Journal Article
Journal
Nuclear Techniques; ISSN 0253-3219; ; v. 29(5); p. 358-361
Country of publication
AMIDES, AMINES, AROMATICS, AUTONOMIC NERVOUS SYSTEM AGENTS, BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, CARBOXYLIC ACIDS, CARDIOTONICS, CARDIOVASCULAR AGENTS, DRUGS, HOURS LIVING RADIOISOTOPES, HYDROXY COMPOUNDS, INTERMEDIATE MASS NUCLEI, INTERNAL CONVERSION RADIOISOTOPES, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, MEMBRANE PROTEINS, MONOCARBOXYLIC ACIDS, NEUROREGULATORS, NUCLEI, ODD-EVEN NUCLEI, ORGANIC ACIDS, ORGANIC COMPOUNDS, ORGANIC NITROGEN COMPOUNDS, PHENOLS, POLYPHENOLS, PROTEINS, RADIOISOTOPES, SYMPATHOMIMETICS, TECHNETIUM ISOTOPES, YEARS LIVING RADIOISOTOPES
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