[en] ACRO was developed as a computer program to calculate internal exposure doses resulting from acute or chronic inhalation and oral ingestion of radionuclides. The ICRP Task Force Lung Model (TGLM) was used as the inhalation model in ACRO, and a simple one-compartment model was used as the ingestion model. The program is written in FORTRAN IV, and it requires about 260 KB memory capacity

[en] The computer code ORION has been developed to evaluate the environmental concentrations and the dose equivalent to human organs or tissue from air-borne radionuclides released from multiple nuclear installations. The modified Gaussian plume model is applied to calculate the dispersion of the radionuclide. Gravitational settling, dry deposition, precipitation scavenging and radioactive decay are considered to be the causes of depletion and deposition on the ground or on vegetation. ORION is written in the FORTRAN IV language and can be run on IBM 360, 370, 303X, 43XX and FACOM M-series computers. 8 references, 6 tables

[en] Ultraviolet radiation suppresses the semiconservative DNA replication in mammalian cells. The rate of DNA synthesis is initially depressed and later recovers after low doses of UV radiation in human cells. Such a response is more sensitive to UV radiation in cells derived from patients with xeroderma pigmentosum (XP) than that in normal human cells. The relative rate of DNA synthesis is not always correlated with cell survival because, unlike cell survival, the dose-response curve of the relative rate of DNA synthesis shows the biphasic nature of the sensitivity. In the experiments reported herein, the total amount (not the rate) of DNA synthesized during a long interval of incubation which covers the period of inhibition and recovery (but not longer than one generation time) after irradiation with various doses of UV radiation was examined in normal human and XP cells, and was found to be well correlated with cell survival in all the cells tested. (Auth.)

[en] It was of interest to examine the effects of rifampin on ultraviolet-irradiated mammalian cells to know whether there is a rifampin-sensitive process in mammalian cells as in Escherichia coli. In this communication, we report that a non-toxic concentration of rifampin enhanced the lethality of ultraviolet-irradiated Chinese hamster V79 cells, but had no effect on the ultraviolet-induced mutation frequency in these cells. (orig./AJ)

[en] The biological effects of DNA-damaging agents are codetermined by the structural characteristics of the lesions, the quality and extent of the local distortion of DNA and chromatin structure, and the mode(s) of damage processing used by a given type of cell. Persistent damage (i.e., damage that is not removed before it is reached by DNA replication) may be mostly responsible for mutagenesis and carcinogenesis. To understand the effects of environmental physical and chemical DNA-damaging agents on human health, the mechanisms of damage processing used by human cells have to be elucidated. We report our studies of the excision of gamma-ray products of the 5,6-dihydroxydihydrothymine type (t₀/sub 2//sup γ/) in normal human fibroblasts and in fibroblasts from patients with the hereditary diseases Fanconi's anemia (FA) and ataxia telangiectasia (AT). Both diseases are characterized by chromosomal instability and increased susceptibility for the development of cancer. Formation and repair of DNA-benzo[a]pyrene adducts were studied in baby hamster kidney cells, secondary mouse embryo cells, and human lymphoma. The relative persistence of DNA-B[a]P may explain the high mutagenicity of the 7,8-dihydroxy-9,10-epoxy-tetrahydrobenzo[a]pyrene metabolites in rodent cells that has been observed by several investigators

[en] Bursts of ∼60 kHz activity on Mirnov coils occur frequently in NSTX plasmas and these are accompanied by bursts of neutral beam ion loss over a range in pitch angles. These losses have been measured with a scintillator type loss probe imaged with a high speed (>10,000 frames/s) video camera, giving the evolution of the energy and pitch angle distributions of the lost neutral beam ions over the course of the events. The instability occurs below the TAE frequency in NSTX (∼100 kHz) in high beta plasmas and may be a beta driven Alfven acoustic (BAAE) mode.

[en] HeLa cells were incubated either with BrdUrd (5 x 10^-5M) and deoxycytidine (10^-5M) for 18 hr (corresponding to one generation time) or with gallium citrate (10^-5M) for 24 hr. The cells on the membrane filter were irradiated with monochromatic synchrotron radiation at 0.90 A, 1.00 A, or 1.14 A and cell survival was determined by colony-forming ability. The results show that the sensitivity of BrdUrd-labeled cells was higher when they were irradiated at 0.90 a than at 100 A, but cells without BrdUrd showed no difference in sensitivity when irradiated at these two wavelengths. The growth curve of HeLa cells in the presence of gallium citrate (10^-4M). Shows that during the test period of 20-60 hr of colony-forming ability was not affected although the growth rate decreased slightly. Data show no increase in the sensitivity of gallium-labeled HeLa cells over that of controls to irradiation with monochromatic synchrotron radiation at 1.14 A, slightly shorter than the K absorption edge for the gallium (1.196 A). Since gallium has been shown to concentrate in lysosome, the present results, suggest that the range of Auger enhancement is not great enough for interaction with DNA in nucleus from lysosome in cytoplasm, although the possibility should be considered that the accumulated number of gallium atoms (∼ 5 x 10⁷/cell) may not be enough to produce detectable enhancement effects

[en] Special individual monitoring has been performed for suspected cases of inhalation of plutonium at the Tokai Works of the Japan Nuclear Cycle Development Institute (JNC). Some experimental data obtained from this special individual monitoring during the past 20 years are presented and discussed in this paper. Our experience suggests the following conclusions. The daily plutonium excretion rate, normalised to the total excretion for the first 5 days after inhalation, was approximately in agreement with the latest ICRP 78 dosimetric model. Maximum faecal excretion is observed on the second day after inhalation of plutonium compounds. On the other hand, the activity ratio for total alpha activity observed in early faeces to that detected in nasal swabs showed a wide distribution range, and it was proven that variations in this ratio followed a log-normal distribution. The logarithmic mean probability is about 2.1 for PuO₂ and about 15.7 for Pu(NO₃)₄. In practice, a conservative dose assessment from nasal swabs can be performed on the basis of these experimental ratios. (author)

[en] A Solid State Neutral Particle Analyzer (SSNPA) array has been installed on the National Spherical Torus Experiment (NSTX). The array consists of four chords viewing through a common vacuum flange. The tangency radii of the viewing chords are 60, 90, 100, and 120 cm. They view across the three co-injection neutral beam lines (deuterium, 80 keV (typ.) with tangency radii 48.7, 59.2, and 69.4 cm) on NSTX and detect co-going energetic ions. A silicon photodiode used was calibrated by using a mono-energetic deuteron beam source. Deuterons with energy above 40 keV can be detected with the present setup. The degradation of the performance was also investigated. Lead shots and epoxy are used for neutron shielding to reduce handling any hazardous heavy metal. This method also enables us to make an arbitrary shape to be fit into the complex flight tube

[en] Radiological effects to the regional environment around Tokai Reprocessing Plant (TRP) were assessed using both actual environmental radiological monitoring data and doses estimated by mathematical models. The environmental monitoring showed no increase of radiological level except for the influences from atmospheric explosion tests, the Chernobyl accident, and domestic accidents. Estimated annual effective dose for the public was only 0.1% of the annual dose limit recommended by the ICRP. (author)