[en] N-(3,5-Dichlorobenzyl)-4-(fluoromethoxy) benzenecarboximidamide labeled with carbon-14 was prepared from 4-hydroxy-benzonitrile-[cyano-¹⁴C]. (author)

[en] Labelled organic compounds have been widely applied to solve the research problems in life, science and chemistry. The preparation of labelled compounds, with carbon-14 and tritium-3 are probably more extensively and variously used in compare with any other isotopes. These isotopes emit only beta-particle. In this paper the synthesis of DL[³H] Leucine which was prepared for the first time in Iran is described. This compound is used for diagnosis of talasemi disease. The synthetic pathway is achieved by using the condensation of methyl ally chloride with diethyl acetamido malonate in the presence of sodium ethoxid in ethanol. In the next step of the synthesis, the latter compound was hydrogenated with ³H₂(g) over the Adams catalyst in chloroform, which was produced ethyl 2-acetamido-2-carbethoxy-4-methyl pentanoate with a yield of 100%. In final step, the resulted product was converted directly to [4,5-³H] Leucine with the specific activity 5 Ci/mmol, by reflaxing with the hydrobromic acid of 48%

[en] Two 1,2,3-triazole anticonvulsants, 1-(4-methylsulfone-phenyl)-5-(4-fluoro-phenyl)-5-[¹⁴C]-1,2,3-triazole and 1-(4-sulfonamide-phenyl)-5-(4- fluoro-phenyl)-5-[¹⁴C]-1,2,3-triazole, both labeled with carbon-14 in the 5-position were prepared from para-fluoro-benzonitrile-[cyano-¹⁴C]. (author)

[en] Three 1,2-diaryl pyrroles selective COX-2 inhibitors, 2-(4-fluorophenyl)-5-methyl-1-(4-methylsulfonyl-phenyl)-1H pyrrole, 2-(4-fluorophenyl)-1- [4-(methylsulfonyl) phenyl]-1H-pyrrole and 4-[2-(4-fluorophenyl)-1H-pyrrol-1-yl]benzenesulfon-amide, all three labeled with ¹⁴C in the 2-position were prepared from para-fluoro-benzaldehyde-[carbonyl-¹⁴C]. (author)

[en] Aryl N-alkoxycarbamates labeled with carbon- 14 have been synthesized from aryl nitrile-[cyano-¹⁴C] as part of a 2-step sequence. The resulted carbamates were treated with amines, generating [carbonyl-¹⁴C]-Ureas in high yield and purity. (author)

[en] The mechanism of action and metabolism of clozapine which is considered as a complicated drug used in psychopharmacology, is not completely understood. The effects of this compound in human body are related to some interactions of this compound with serotonin and dopamine neurotransmitter receptors. To further elucidate the mechanism of action and to support the ongoing drug metabolism studies, [^I4^C] clozapine with a suitable radiochemical purity was synthesized in the Nuclear Science Research School of the AEOI. In this report, the radiochemical and chemical purity of [¹4^C] clozapine were determined by the liquid scintillation and the reversed phase-HPLC, respectively. Separation of [^I4^C] clozapine and its synthesized interface products were carried out using a C₈ optimal column and a UV detector at 254 nm. The mobile phase consisted of acetonitril- buffered aqueous solution of sodium phosphate with a flow rate of 1 ml/min. The detection limit and the analytical precision of RP-HPLC method were 0.1 ng and 1-3.4%, respectively. The chemical purity of the synthesized clozapine was >99%. For determination of the activity and the radiochemical purity, a liquid scintillation spectrometer was used and the counting was made by direct addition of samples to ACS (Amersham) solution. The specific activity of the synthesized clozapine was 10 micro Ci/mg and the radiochemical purity higher than 99% was obtained

[en] One of the important herbicide, that can be used for the practical mechanism investigations and studies of metabolism functions of different plants is 2,4 dichlorophenoxy acetic acid compound. In this article, the production method for labeling the titled compound is explained. At the first stage of this research work, barium[¹⁴C] carbonate is converted into potassium [¹⁴C] by using potassium azid at a reasonable temperature. Then, after a few synthesis reaction, the compound 2,4 dichlorophenoxy methyl iodide is produced via 2,4 dichlorophenoxy as a starting material. At the next stage, the real material as a herbicide: 2,4 dichlorophenoxy acetic acid [carboxy- ¹⁴C] is prepared and produced, by the coupling reaction between 2,4 dichlorophenoxy methyl iodide and potassium [¹⁴C] cyanide, and then the resulting nitrile has been hydrolyzed