[en] Iohexol 350 mg I/ml (Omnipaque) was compared with the routine contrast medium meglumine, Na-Ca-metrizoate 370 mg I/ml (Isopaque Coronar) in coronary angiography in 30 patients. A randomized, double blind, cross-over design was employed. Angiographic image quality, ECG, heart rate, aortic blood pressure and adverse reactions were recorded. Excellent image quality was obtained with both media. Except for one single event of hypotension, only few and minor changes in the parameters measured were recorded. No distinct difference between the two media was found. Iohexol seems to be suitable for selective coronary angiography. (Auth.)

[en] Iopentol is a niw los-osmolar non ionic contrast medium (CM). In this trial iopentol was compared with iohexol in a double blind cross-over cardioangiography study in 38 patients with stable angina. The image quality was excellent in 94% and sufficient in 5% of the injections. Myocardial depressive effects after LV injection were not observed, except for a slight and transient increase of LV end diastolic pressure. Serious arrhythmias were not seen and the tolerability of both CM was excellent. It is concluded that iopentol and iohexol are equally well suited for routine use in cardioangiography (author). 6 refs.; 2 tabs

[en] The first investigation of iohexol in human cardioangiography is presented. Slight subjective reactions as well as moderate and transient influence on hemodynamics and ECG parameters were recorded. Analysis of serum enzymes indicated no myocardial injury. Good or excellent films of the left ventricle, aortic root and coronary arteries were obtained. (Auth.)