[en] When radiation was used for the treatment of chest malignant tumor, the heart will be irradiated inevitably, which led to radiation-induced heart disease (RIHD). With the improvement of radiotherapy and chemotherapy, the survival time of cancer patients had been extended Therefore, the research on RIHD had been attracted more and more attention. At present, scholars have not formed a unified understanding of this disease and there is no effective method to prevent its occurrence in clinical practice at home and abroad. Animal model research can provide reliable evidence for clinical treatment and prevention of this disease. For this reason, this paper reviews and analyzes the animal model research of radioactive heart injury in recent years, which aiming to provide reference for the development of follow-up experiments and clinical application. (authors)

[en] Highlights: • DANCR was increased in OA. • DANCR inhibition suppressed OA chondrocytes proliferation and induced cell apoptosis. • DANCR-miR-577/SphK2 axis play important roles in OA. Long noncoding RNAs (lncRNAs) have been known to be involved in multiple diverse diseases, including osteoarthritis (OA). This study aimed to explore the role of differentiation antagonizing non-protein coding RNA (DANCR) in OA and identify the potential molecular mechanisms. The expression of DANCR in cartilage samples from patients with OA was detected using quantitative reverse transcription–polymerase chain reaction. The effects of DANCR on the viability of OA chondrocytes and apoptosis were explored using cell counting kit 8 assay and flow cytometry assay, respectively. Additionally, the interaction among DANCR, miR-577, and SphK2 was explored using dual-luciferase reporter and RIP assays. The present study found that DANCR was significantly upregulated in patients with OA. Functional assays demonstrated that DANCR inhibition suppressed the proliferation of OA chondrocytes and induced cell apoptosis. The study also showed that DANCR acted as a competitive endogenous RNA to sponge miR-577, which targeted the mRNA of SphK2 to regulate the survival of OA chondrocytes. In conclusion, the study revealed that lncRNA DANCR might promote the proliferation of OA chondrocytes and reduce apoptosis through the miR-577/SphK2 axis. Thus, lncRNA DANCR might be considered as a potential therapeutic target for OA treatment.