[en] Fourteen years of clinical experience with accelerated fractionation is summarized. Regimes using two or three sessions every treatment day over a short period of time offer not only practical advantages but also fast palliation and a chance of improved therapeutic ratio, namely in radiotherapy of quickly repopulating tumours. This method can be modified for almost every indication of external beam photon treatment and is especially advantageous for centres which use their machines for long hours and have difficulty with daily transport of their out-patients. (author)
Source
International Atomic Energy Agency, Vienna (Austria); World Health Organization, Geneva (Switzerland); Proceedings series; 455 p; ISBN 92-0-010087-2; 
; 1987; p. 147-154; IAEA; Vienna (Austria); International symposium on radiotherapy in developing countries - present status and future trends; Vienna (Austria); 1-5 Sep 1986; IAEA-SM--290/11; 19 refs, 1 tab.
; 1987; p. 147-154; IAEA; Vienna (Austria); International symposium on radiotherapy in developing countries - present status and future trends; Vienna (Austria); 1-5 Sep 1986; IAEA-SM--290/11; 19 refs, 1 tab.
[en] Since 1972 over 100 patients have been treated by frequent daily sessions of radiotherapy with a short overall time. Cobalt 60 teletherapy and 250 kV X-ray beams have been used with radical or palliative dosage. The tolerance to these regimes of the skin, breast, chest wall, neck, lung and pelvis is discussed and the tumour responses described. Radiotherapy by multiple daily sessions is clinically possible and often an advantage. Its therapeutic ratio is not inferior to comparable regimes using longer intervals. (author)
Journal
British Journal of Radiology; ISSN 0005-1285; ; v. 51(605); p. 363-369
; v. 51(605); p. 363-369
[en] The technique of matched triplets was used to evaluate the influence of overall treatment time on the outcome of breast carcinoma treated by primary external beam radiotherapy. 45 patients treated using accelerated radiotherapy over 1-2 weeks were matched with suitable patients treated by a conventional regime over 5-6 weeks and these pairs then further matched with patients treated by 9-10 wee ks courses. Neither sequential analysis nor Kaplan-Meier method showed any significant difference in local control or disease specific survival between the three groups. Three regimes which were considerably different in overall time provided comparable results, but these were achieved by different in total dose
Source
Rao, R.S.; Deo, M.G.; Sanghvi, L.D.; Mittra, I. (eds.); v. 2; ISBN 88-323-1030-9; ; 1994; p. 1419-1423; Monduzzi Editore; Bologna (Italy); 16. international cancer congress; New Delhi (India); 30 Oct - 5 Nov 1994
; 1994; p. 1419-1423; Monduzzi Editore; Bologna (Italy); 16. international cancer congress; New Delhi (India); 30 Oct - 5 Nov 1994
[en] Purpose: To evaluate the results of interstitial radiotherapy of anorectal tumors. Patients and Methods: From 1972 to 1993, one of the authors treated 45 patients by an interstitial implant for anorectal tumors. Of these, 33 patients suffered from primary tumors, 19 from squamous carcinoma, 2 from basaloid carcinoma of the anus and the other 12 from primary adenocarcinoma of the rectum. Of 12 patients treated for local recurrence, 10 had adenocarcinoma and 2 squamous cell carcinoma. Of the 33 patients with primary tumors, 27 received a course of external-beam radiotherapy before the implant. The median follow-up was 35 months. Results: Local response depended on the tumor volume treated. All 21 anal tumors showed complete response, 5 patients developed local recurrence and 4 distant metastases; 3 died from their disease. Of 12 rectal adenocarcinomas, 9 responded completely, 4 patients developed local recurrence and 4 distant metastases; 6 died from their disease. In the last group of 12 patients who were treated for recurrent tumors, 7 responded completely. One patient developed local recurrence and 9 distant metastases, only 4 are alive. Conclusions: A combination of external-beam and interstitial radiotherapy is a relatively simple, non-mutilating, but well-tolerated and very effective method of treatment for early carcinoma of the lower rectum and a nus. (orig.)
[de]
Ziel: Die Auswertung der Ergebnisse der interstitiellen Radiotherapie anorektaler Geschwuelste. Patienten und Methode: Das Krankengut bestand aus 45 Patienten mit anorektalen Tumoren, die im Zeitraum von 1972 bis 1993 durch interstielle Implantate behandelt wurden. Von 33 Patienten mit primaeren Tumoren wurden 19 wegen spinozellulaerer, zwei wegen basozellulaerer Karzinome des Anus, weitere zwoelf wegen Adenokarzinomen des Rektums behandelt. Ausserdem wurden zwoelf Patienten wegen Lokalrezidiven, davon zehn wegen Adeno- und zwei wegen Spinozellularkarzinomen bestrahlt. Von den 33 Patienten mit primaeren Tumoren wurden 27 vor dem Implantat mit Teletherapie perkutan bestrahlt. Die mediane Nachbeobachtungszeit betrug 35 Monate. Ergebnisse: Der Behandlungserfolg war von der Tumorgroesse abhaengig. In der Gruppe von 21 Patienten mit Analtumoren, bei der eine komplette Tumorremission erreicht wurde, traten in fuenf Faellen Lokalrezidive, in vier Faellen Fernmetastasen auf, drei Patienten sind bisher verstorben. Bei zwoelf rektalen Adenokarzinomen wurde neunmal eine komplette Tumorremission erreicht, bei vier Patienten mit Fernmetastasen. Sechs Patienten verstarben. In der Gruppe von zwoelf Patienten, die wegen Lokalrezidiven behandelt wurden, kam es bei sieben zu einer kompletten Remission, bei einem davon entwickelte sich spaeter ein zweites Lokalrezidiv. Es traten neun Fernmetastasen auf, acht Patienten verstarben. Schlussfolgerung: Die Kombination der perkutanen Bestrahlung mit interstinellem Implantat erweist sich als relativ einfache, aber sehr effektive Methode der Behandlung von fruehen analen und tiefer liegenden Rektumkarzinomen. (orig.)Journal
[en] This study investigates the changes in the Ki67 labeling index during radiotherapy (RT) of seven patients with primary breast carcinoma, one patient with metastatic bronchial squamous cell carcinoma and one patient with a para-umbilical deposit of a large bowel adenocarcinoma. The material was taken by fine needle aspiration either from the primary tumors or the metastases. In four patients with primary breast carcinoma, we observed a drop in the Ki67 labeling index after 24 h (2 Gy), but an increase after 18 days (26 Gy). In one patient the pattern was different. An increase after the initial fraction was followed by a decrease after 18 days of radiotherapy. In two patients with primary breast carcinoma, where the second sample was aspirated after 72 h (3 fractions of RT, 6 Gy), the values of Ki67 indexes before RT were higher than after RT. In two patients where the material was aspirated from metastatic deposits, we observed an increase of Ki67 labeling index after 24 h (2 Gy). Possible explanations, including repopulations following the suppression of the synthesis in the originally active clonogens after radiation injury, are discussed. (author)
Journal
Neoplasma; ISSN 0028-2685; ; v. 43(2); p. 89-92
; v. 43(2); p. 89-92