[en] The paper create data base which is used by 'Quanty U' software based on the drilling data of Zaohuohao uranium deposit. By 'Gxplorer' software creating a single hole model unit, profile constraints, key geological interface model unit, to produce digital and visual inquiry and analysis of the whole process which include the uranium exploration database, geological map, three-dimensional geological modeling. The establishment of three-dimensional geological model on Zaohuohao uranium deposit can reflect the characteristics of geological body in three-dimensional space form and provides a new idea for further mining ore resource potential and help to make decision for mining use, at the same time briefly discussed the significance of three-dimensional geological modeling. (authors)

[en] An orthorhombic structure boron nitride (O-BN, space group: Pbam) was studied by first-principles calculations. The structural, elastic properties, Possion’s ratio, elastic anisotropy, hardness, wave velocity and Debye temperature of O-BN were investigated by density functional theory method with the ultrasoft pseudopotential scheme in the frame of the generalized gradient approximation (GGA). The results for the equilibrium structural parameters of O-BN, c-BN and w-BN are consistent with experimental values and other theoretical results. It is found that O-BN has a bulk modulus of 365 GPa, a shear modulus of 362 GPa, a Young’s modulus of 816 GPa, the hardness of 59.2 GPa, a large Debye temperature 1842 K and a small Possion’s ratio 0.13 under zero temperature and zero pressure; O-BN has elastic anisotropy, and shear anisotropy of shear plane {100}, {010} and {001} increases with the increase of pressures. When the pressure increases, the compression along the b-axis is much larger than those along the a-axis and b-axis in the basal plane, and the compression along the c-axis is the smallest; O-BN can satisfy the criteria for mechanical stability of orthorhombic phase, so it is mechanically stable. (paper)

[en] Objective: To explore the value of carcinoembryonic antigen (CEA), cytokeratin 19 fragment (CYFRA21-1), neuron-specific-enolase (NSE), progastrin releasing peptide (Pro-GRP), squamous cell carcinoma antigen (SCC), and carbohydrate antigen 125 (CA125) in the diagnosis and differential diagnosis of lung cancer and pulmonary tuberculosis. Methods: The levels of CEA, CYFRA21-1, NSE, Pro-GRP, SCC and CA125 in serum of 138 patients with lung cancer, 138 patients with pulmonary tuberculosis and 138 health examiners (controls) were measured by electrochemical method, and the results were used to evaluate its diagnostic value in lung cancer and pulmonary tuberculosis. Results: The serum levels of CEA, CYFRA21-1, NSE, Pro-GRP and SCC in patients with lung cancer were significantly higher than those of pulmonary tuberculosis patients and the healthy control group. The serum level of CA125 in patients with pulmonary tuberculosis was significantly higher than those of patients with lung cancer and healthy control group. The level of Pro-GRP, NSE in patients with small cell lung cancer (SCLC) were significantly higher than patients with non-small cell lung cancer (NSCLC). The level of CYFRA21-1, SCC, and CA125 in NSCLC were significantly higher than SCLC. The level of CEA and CA125 in the adenocarcinoma group were significantly higher than the squamous cell carcinoma group, while the levels of CYFRA21-1 and SCC in the squamous cell carcinoma group were significantly higher than the adenocarcinoma group (P < 0.05). The ROC curve analysis showed that the area under the curve (AUC) of combined detection of 6 tumor markers were 0.993 and the sensitivity was increased to 96.4%, which was superior to that of single-index detection, and combined detection was statistically significant compared with the pulmonary tuberculosis group (P < 0.05). When tested separately, the AUC of CA125 in the diagnosis of tuberculosis was 0.928 and the sensitivity was 81.9%, which was significantly superior to other indexes. The AUC of NSE and Pro-GRP in the SCLC group were 0.961 and 0.938, and the sensitivity were 85% and 92.5%, respectively. The AUC of CYFRA21-1 and SCC in the squamous cell carcinoma group were 0.977 and 0.933, and the sensitivity were 90.9% and 87.9%, respectively, which was significantly superior to other indexes. The AUC of CEA in the adenocarcinoma group were 0.957, which was significantly superior to other indexes, with the sensitivity of 89.2%. Conclusion: The level of tumor markers in patients is related to benign, malignant and pathological types, and combining multiple tumor markers for detection is more conducive to clinical diagnosis. (authors)

[en] The barrier at CdTe/metal interface severely limits the efficiency of CdTe photovoltaic devices. Herein, the effectiveness of a thermally evaporated Sb${}_2$Se${}_3$ buffer layer as a back contact in CdTe solar cells is investigated, revealing a significant enhancement in device performance. Through optimization of Sb${}_2$Se${}_3$ thickness, a remarkable increase in the open-circuit voltage (V${}_{OC}$) to 804 mV is achieved, leading to a substantial efficiency improvement of 12.84% when compared to the Au-only back contact device. X-ray photoelectron spectroscopy (XPS) reveals a well-matched energy band alignment at CdTe/Sb${}_2$Se${}_3$ interface, confirming favorable conditions for hole transport. To further enhance the device performance, Cu doping is implemented in the Sb${}_2$Se${}_3$ film, resulting in additional improvements to the V${}_{OC}$ and fill factor (FF) of the Cu-doped configuration to 819 mV and 72.35%, respectively, while also enhancing the overall efficiency to 14.3%. (© 2023 Wiley‐VCH GmbH)

[en] Electromagnetic compatibility (EMC) is very important for intelligent instruments, and it is an important guarantee for its reliable operation. The complexity of EMC is mainly reflected in how to quickly and accurately locate the disturbance source, effectively suppress the disturbance source, and correctly judge the disturbance coupling path. Intelligent instruments have similar hardware characteristics. In this paper, the characteristics of common hardware characteristics of disturbance source and coupling path are analyzed, the equivalent antenna model of disturbance is analyzed, and the disturbance suppression method is given. Finally, the correctness of the method is verified by experiments. (paper)

[en] Highlights: • Toxicity of MC-LR on ZF4 cells was determined. • MC-LR-regulated genes and alternative splicing events were identified. • The effects of MC-LR on signaling pathways are highly time-dependent. • A gene regulatory network was constructed to identify the potential regulators mediating the cellular transcriptional responses to MC-LR. -- Abstract: Microcystin-LR (MC-LR) is a highly toxic hepatotoxin that poses great hazards to aquatic organisms and even human health. The zebrafish liver cell line (ZFL) is a valuable model for investigating toxicity and metabolism of toxicants. However, the toxicity of MC-LR and its effects on gene transcription of ZFL cells remains to be characterized. In this study, we determined the toxicity of MC-LR for ZFL cells and investigated the effects of MC-LR on cellular transcriptome dynamics. The EC₅₀ of MC-LR for ZFL cells was 80.123 μg/mL. The ZFL cells were exposed to 10 μg/mL MC-LR for 0, 1, 3, 6, 12 or 24 h, and RNA-sequencing was performed to analyze gene transcription. A total of 10,209 genes were found to be regulated by MC-LR. The numbers of up- and down-regulated genes at different time points ranged from 2179 to 3202 and from 1501 to 2597, respectively. Furthermore, 1543 genes underwent differential splicing (AS) upon MC-LR exposure, of which 620 were not identified as differentially expressed gene (DEG). The effects of MC-LR on cellular functions were highly time-dependent. MAPK (mitogen-activated protein kinase) and FoxO (forkhead box O) signaling pathways were the most prominent pathways activated by MC-LR. Steroid biosynthesis and terpenoid backbone biosynthesis were the most enriched for the down-regulated genes. A gene regulatory network was constructed from the expression profile datasets and the candidate master transcription factors were identified. Our results shed light on the molecular mechanisms of MC-LR cellular toxicity and the transcriptome landscapes of ZFL cells upon MC-LR toxicity.

[en] A 500 h life-test of direct methanol fuel cell (DMFC) was conducted in a single cell. X-ray diffraction (XRD) and transmission electron microscopy (TEM) images showed that after life-test, the particle size of electrocatalysts increased both in anode and cathode, and the degree is higher in cathode. Electrochemical areas (ECAs) of anode and cathode catalyst were evaluated by CO-stripping and hydrogen-desorption test, respectively. It was found that the ECA loss is higher than the specific surface area (SSA) loss (determined by XRD) that merely due to the sintering of the electrocatalyst particles. Energy dispersive X-ray analysis (EDX) revealed a crossover of ruthenium from the anode side to the cathode side in the cell