[en] Objective: To evaluate the relationship between deep vein thrombosis (DVT) and pulmonary embolism (PE) and the origin of PE. Methods: Fifty normal people and 200 patients with highly suspected PE and DVT of lower extremities underwent pulmonary perfusion/ventilation (P/V) imaging with ⁹⁹Tc^m-macroaggregated albumin (MAA) and ⁹⁹Tc^m-glucose phosphate (GP), 15 patients among them also underwent pulmonary artery angiography. Results: Fifty normal people gave normal images of P/V. Among 200 patients, 175 were with multiple PE, 25 were normal; among PE patients, 128 were with lower extremity venous disorders (73.14%), 25 cases without PE were all with extremity venous disorders; among 153 with lower extremity venous diseases, 128 were with PE (83.66%); 119 of them had DVT, 101 cases' PEs originated from iliofemoral vein thrombosis (84.87%). Conclusion: It is effective to diagnosis PE and its origin with combinative use of pulmonary perfusion/ventilation imaging and lower extremity vein imaging

No abstract available

[en] Objective: Pulmonary ventilation/perfusion (V/Q) imaging was used in the diagnosis of atypical subsegmental pulmonary embolism(PE) and monitoring the response to anti-coagulation. Methods: A total of 141 patients (58 men, 83 women, 40-83 years) underwent ⁹⁹Tc^m-MAA and ⁹⁹Tc^m-Technegas pulmonary V/Q imaging, and then underwent pulmonary perfusion imaging after 1-24 months oral anticoagulative therapy. Fourteen cases had lower limbs venous lesions, 45 diabetes mellitus or hyperlipaemia, and 63 the history of invasive diagnosis or therapy management recently. Pre- and post-anticoagulation images were compared and combined with clinical information and other imaging modalities to assess the subsegmental PE. Results: All pulmonary perfusion images showed defects in different sizes with normal pulmonary ventilation images. After therapy, the radioactive uptake and distribution in both lungs improved in 118/141 (83.69%) cases. The post-treatment scans were judged normal in 35 patients, obviously improved in 49, mildly improved in 34. Conclusion: Pulmonary V/Q imaging provided accurate information in both diagnosis and post-therapy monitoring of atypical subsegmental PE. (authors)

[en] Objective: To evaluate the accuracy and safety of domestic made adenosine in ⁹⁹Tc^m- methoxyisobutylisonitrile (MIBI) myocardial perfusion SPECT during adenosine stress for the diagnosis of coronary ischemia. Methods: One hundred and two patients [73 men, 29 women, mean age (57 ± 10.4) years] with suspected coronary artery disease underwent adenosine stress and rest myocardial perfusion imaging. Adenosine was infused intravenously at a constant rate of 0.14 mg·kg^-1·main^-1 for 6 min. At the end of 3 min, 925 MBq of ⁹⁹Tc^m-MIBI was injected. In 70 patients coronary angiography was also performed within one week. Results: Thirty-nine patients had significant coronary artery stenosis and 31 patients had normal result. Adenosine stress myocardial perfusion scintigraphy was abnormal in 32 out of the 39 patients in coronary artery stenosis (sensitivity, 82.05%), and normal in 26 out of the 31 patients with normal angiography (specificity 83.87%). The positive and negative predictive values were 86.49% and 78.79% respectively. The frequency of side-effects was slight and transient with the incidence of 85.29%. Conclusion: The domestic made adenosine in stress myocardial perfusion imaging is safe and sensitive for detecting myocardial ischemia. (authors)

[en] Objective: There is great interest in the assessment of functionally relevant coronary artery lesions and its value in coronary artery disease (CAD) management by hybrid SPECT/CT. The objective of this study was to evaluate the clinical value and the feasibility of imaging of hybrid SPECT/CT in detecting the 'functionally relevant coronary artery lesions (FRCAL)'. Methods: Forty patients with suspected or known CAD performed computed tomography coronary angiography (CTCA) and stress/rest myocardial perfusion imaging (MPI) with ⁹⁹Tc^m-methoxyisobutyhsomtrile (MIBI) by hybrid SPECT/CT. Stress/rest MPI was performed with standard two-day protocol, and CTCA was performed the second day. Adenosine was infused intravenously at a constand rate of 0.14 mg·kg^-1·min^-1 for 6 min. CTCA was performed with standard contrast medium autotrack sequence. Images of MPI and CTCA were fused by special fusion software (AutoQUNANT'7.0) in order to evaluate the functional relationship between myocardial ischemia and CAD, videlicet 'FRCAL'. Results: Twenty of the 40 patients had coronary atherosclerosis, malformation or coronary stenosis, with a total of 33 diseased coronary vessels (15 left anterior descending coronay artery, 9 left circumflex coronary artery and 9 right coronary artery). The remaining 20 patients had normal results. MPI were normal in 22 and 18 showed myocardial ischemia and (or) infarct. The ratio of normal MPI in normal CTCA was 92.47% (86/93) by SPECT/CT imaging. The positive rates of detecting ischemia were 42.86% (6/14, <75% diameter stenosis) and 92.31% (12/13, >75% diameter stenosis or blockage). About 20. 83% (25/120) of all the narrowed coronary arteries were determined to be 'FRCAL' and 25.93% (7/27) of the patients without coronary, stenosis had myocardial ischemia. And then 15.38% (2/13) of the patients with CAD avoided invasive procedures (that was coronary angiography). About 42.86% (6/ 14) needed drug treatment or coronary revascularization (<75% diameter stenosis). There was 1 patient with 1 vessel >75% diameter stenosis but no coronary revascularization. Conclusion: Fusion imaging of MPI and CTCA by hybrid SPECT/CT has clinical values in diagnosing CAD and selecting the 'FRCAL' patients who might benefit from further revascularization procedures. (authors)