[en] To determine the efficacy of radionuclide therapy using Re-188 and P-32 patches for treatment of keloids. Twenty-four patients with 61 keloid lesions who received radionuclide patch therapy were included in the study. Shape and surface area of the lesions was calculated. Patches conforming to the shape and size of the individual lesions were applied superficially so as to deliver 50 Gy/cm² of surface radiation dose. Randomized patients for treatment with P-32 and Re-188 were matched for age, sex, number and extent of lesions into two groups (P > 0.05). Seventeen, 14, and 10 lesions demonstrated a reduction in lesion size of 50%-80%, 80%-99%, and complete disappearance, respectively. There was a >50% decrease in lesion size in 41 (67%) lesions. Sixteen (76%) lesions in P-32 group demonstrated decrease in lesion size of more than 50% as compared to 25 (62%) lesions in Re-188 group, the difference not being statistically significant (P > 0.5). Spectrum of radiation dermatitis ranging from pain itching, erythema, crusting, desquamation, and re-epithelialization was observed as side effects in patients. Radionuclide therapy using Re-188 and P-32 as radioactive skin patches is an effective and safe therapeutic option for the treatment of keloids. (author)