[en] This paper is part of an ongoing research project designed to evaluate the effect of climate change on reservoir operation policies in the Mississippi Valley Conservation Authority. The study used the results from a first paper, including projected daily temperature and precipitation, for future streamflow calculation. This paper presented the development, calibration and validation of a rainfall-runoff NAM model for the Mississippi River watershed. The calibrated Mike11/NAM model was fed with predicted climatic data to generate long term future streamflow in the basin. Forecast flows were run in a Mike 11/HD model to estimate the corresponding lake levels. The storages and flows at Shabomeka Lake, Mazinaw Lake and Marble Lake were simulated. The results showed that climate change is likely to have implications for reservoir operations in the Mississippi River watershed, which will include changed water level regimes due to modifications in the projected future streamflow hydrograph to meet desired lake levels.