[en] Objective: To evaluate the differential diagnostic significance of determination of CK19 mRNA contents in the effusion fluid in malignant and benign hydrothorax. Methods: Pleural effusion fluid CK19 mRNA contents was examined with RT-PCR in 43 cases of malignant hydrothorax nd 57 cases of benign hydrothorax. Results: In the patients with malignant hydrothorax, positive rate of CK19 mRNA in pleural effusion fluid was significantly higher than that patients with benign hydrothorax (P < 0.005). The sensitivity of CK19 mRNA detection was 90.7%, the specificity was 70. 2% and the accuracy of CK19 mRNA detection was 70.2%. Conclusion: Detection of CK19 mRNA in pleural effusion fluid could be a promising method for differential diagnosis of benign from malignant cases. (authors)

[en] Neoadjuvant concurrent chemoradiation therapy (nCRT) plus surgery has been a standard treatment for locoregionally advanced esophageal cancer and carcinoma of the gastroesophageal junction (EC/GEJ), but the optimal preoperative radiation dose is still unclear. We performed this systematic review to explore the treatment efficacy and toxicity of different radiation dose levels and find an optimal dose‐fractionation strategy in EC/GEJ patients receiving nCRT.

[en] Highlights: • A facile strategy for the fabrication nitrogen/oxygen co-doped carbon spheres with wrinkled nanocages is proposed. • The optimal carbon (NOCN-850-3) possesses a high specific surface area, high nitrogen and oxygen contents. • NOCN-850-3 exhibits superior supercapacitive behavior to many previous carbon materials. Nitrogen/oxygen co-doped carbon spheres with wrinkled nanocages (NOCN) were successfully synthesized using dendritic fibrous nanosilica (DFNS) as sacrificial solid template, glucose as a carbon source, and melamine as the nitrogen source. The obtained carbon nanocages (NOCN-850-3) exhibit human brain-like winkle shape, high specific surface area (813 m² g⁻¹), high nitrogen (16.24 at%) and oxygen contents (5.36 at%). In addition, the obtained carbon presents good specific capacitance of 311.1 F g⁻¹ at a current density of 0.5 A g⁻¹ in 6 M KOH and remarkable rate performance (118.1 F g⁻¹ at a current density of 30 A g⁻¹) and cycle stability (97.6% retention after 10,000 charge–discharge performance cycles at 10 A g⁻¹). Meanwhile, the NOCN-850-3-based coin-type symmetric supercapacitor exhibits a maximum energy density of 12. 3 W h kg⁻¹ at a power density of 175 W kg⁻¹ and also a relatively low resistance in 6 M KOH aqueous electrolyte. Thus, the unique structure and nitrogen/oxygen co-doping characteristic endue the electrode material a potential application in supercapacitors.