[en] The clinical observation of a case of extremely severe local radiation injury by extremely heterogeneous external irradiation of ¹⁹²Ir is reported. The clinical pathologic change was systematically observed, and the temperature changes in the radiation injured parts were examined by infra-red thermo-imaging. Numbness and convulsion occurred 2 h after irradiation, the earliest erythema and swelling were found 4 h after irradiation. Blistering took place 54 h after irradiation, necrosis and severe pain occurred at the 5th day, the latest erythema and swelling were found 41 days after irradiation, and severe pain occurred at the 5th day, the latest erythema and swelling were found 41 days after irradiation, and blistering and erosive surface of wound took place at the 47th day. Infra-red thermo-imaging examination showed that temperature increased in the early stage of injury, while it decreased in blisters, necrotic regions and in the later stage of injury. The earlier the temperature increased, the severer the injury was. The region of temperature change was consistent with injury extent. Incipient reaction occurred early, injury was exacerbated by radiation sickness and local injury, symptoms were different in early and late stages and varied in severity, the disability was high and pain was severe. The temperature change during infra-red thermo-imaging can be used as one of the objective indices for the diagnosis of injury extent and degree

[en] Objective: To discuss the relationship between morphological characteristics of tumor microvasculature and blood supply type of primary hepatic cell carcinoma (HCC) through DSA. Methods: From Jan. 1998 to Feb. 2002, 32 cases, male 26, female 6, aged 28-76 (mean 50.56 ± 10.52) years, underwent preoperative digital subtraction angiography (DSA) without therapeutic embolization in the 301 hospital and 307 hospital. The intervals between DSA and curative resections were 13-70 (mean 31.89 ± 19.11) days. The diameters of the tumors were 2-23 (8.05 ± 6.17) cm. The blood supply type of tumor, the tumor microvasculature density (MVD), type and diameter of the tumor microvessels, width of tumor trabecular were recorded for these cases. The outcomes were then statistically analyzed. Results: 1) Blood supply of the tumor observed on DSA tended to be positively correlated with type of the tumor microvasculature. 2) MVD of hypovascular tumors were lower than those in moderate and hypervascular tumors. 3) The ratio of diameters between tumor microvessel to the trabecular of the tumor went higher with the increase of HCC blood supply on DSA. Conclusions: 1) The density, the configuration and the distribution of tumor microvasculature were not evenly distributed in HCC. 2) The features of tumor microvasculature possessed distinctive characteristics in different stages of tumor growth, simultaneously with some definite developing rules. 3) Distinct differences in morphological characteristics of tumor microvasculature between different blood supply types of HCC. (authors)

[en] Gastric cancer, one of the most common malignant tumors that can affect the digestive system, poses a serious threat to human life. The survival rate of gastric cancer patients depends on early detection and treatment. The widespread adoption of endoscopy has improved the detection rate of early gastric cancer. Accurate preoperative diagnosis of early gastric cancer is key to developing individualized treatment strategies. Here, nonlinear optical microscopy (NLOM) is used to differentiate between normal gastric mucosae and those with early gastric cancer. Furthermore, the quantitative relationship between submucosal infiltration depth and collagen signals in early gastric cancer is explored. First, the two-dimensional collagen direction angle was measured as an indicator to identify cancerous tissue. The orientation indexes of collagen fibers in normal and cancerous tissues were found to be 0.8511 ± 0.0839 and 0.6466 ± 0.07429 (P < 0.0001), respectively, indicating a significant decrease for the cancerous site. The backscattered second harmonic generation (SHG) signal corresponding to the collagen content and the three-dimensional collagen fiber orientation were then studied for early gastric cancer at different infiltration depths. The backscattered collagen SHG signal (a.u.) in the infiltrated lamina propria, muscularis mucosa, and submucosa were found to be 0.1850 ± 0.0393, 0.0870 ± 0.0189, and 0.0435 ± 0.0163, respectively. The 3D directional variance of collagen corresponding to the three infiltration depth sites were 0.6108 ± 0.0707, 0.6794 ± 0.0610, and 0.8200 ± 0.0618 (P < 0.05), respectively. Significant differences between the early gastric cancer collagen signals at different infiltration depths were observed. Our results indicate that NLOM can differentiate cancerous tissue from normal tissue, and thus diagnose early gastric cancer based on infiltration depth. NLOM provides a new evaluation method for the real-time in situ diagnosis of early gastric cancer and has important clinical significance for preparing accurate individualized treatment guidance. (paper)