[en] TS-d is a rough polysaccharide obtained form polyporaceae JB-2, 615, Kunming mice and rabbit and S180, MA737 tumors were used to study the effects of TS-d. Preliminary results indicated that TS-d is an effective radioprotective and antineoplastic drug with low toxicity and few side effects. Injecting TS-d i.p. to mice at a dosage of 400 mg/kg 60 min before 8.5 Gy γ-irradiation, the survival rate of mice was increased by 43% (P<0.05) as compared with control. Injecting 400 mg/kg of TS-d i.p. into mice 60 min before 7.0 Gy γ-irradiation, the number of WBC, BMC and CFU-S were significantly increased (P<0.01-0.001) as compared with control. The inhibitory rates of TS-d on S180 and MA737 were 46-77% (P<0.05 and P<0.001) and 37-46% (P<0.05 and P<0.05), respectively. TS-d showed significant protective effects on the hematopoietic tissues of rabbits exposed to-γ-irradiation. The LD50_(7d) values of TS-d given i.p. in Kunming mice were 4027.6 +- 434.9 in male and 5115.6 +- 453.5 mg/kg in female, and the LD50_(7d) values of TS-d given i.v. in JB-2 mice were 1389.6 +- 240.8 and 1361.5 +- 208.3 mg/kg, respectively. TS-d had no effect on the growth of mice at the age of four weeks, and neither on the production rate of micronucleus