[en] Earlier the authors synthesized new derivatives of tetrazole, the study of which as biologically active compounds revealed substances exhibiting varied biological effects, including radioprotective activity. The protection of lethally irradiated animals at doses LD_95-99/30 reached 70%, and the toxicity LD₅₀ was 320-2500 mg/kg. In the present study work, the authors continue their work on the search for new radioprotectors among tetrazole derivatives, focusing on 1(2)-aminoalkyl-5-substituted aryltetrazoles I-XXVII. As a result of alkylation of tetrazoles with haloalkylamines, chiefly N₂-isomers were isolated. The toxicity and radioprotective properties of the substances were evaluated for the N₂-isomers and their salts. 9 refs., 4 tabs

[en] The aim of the present investigation was the radioisotopic study of the pharmokinetics of the new, previously synthesized (by the authors) antiviral preparation arbidole, which was authorized for medical use as a prophylactic agent and for treating influenza. Moreover, the investigations have shown that arbidole has an antimetastatic action in experiments on animals. The method of synthesizing arbidole ¹⁴C labeled at two atoms is discussed. It is concluded from the results that the maximal levels of radioactivity in the organs and tissues of mice is recorded during the first hour after peroral administration of ¹⁴C-arbidole. According to the degree of accumulation of the radioactivity, the organs and tissues can be arranged in the following (decreasing) order: liver, blood plasma, kidneys, lungs, spleen, thymus, adrenal glands, lymphatic glands, thyroid glands, hypophysis. Up to 90% of the introduced radioactivity is eliminated from the organs during the first day. 4 refs., 2 tabs

[en] One of the first antitumor drugs -- sarcolysine [4-bis(2-chloroethyl)-aminophenylalanine, mixture of isomers] and its L-isomer, melfalan, have been widely used clinically up to this time. A number of researchers have used various methods to study the pharmocokinetics of the drug in rats, mice, rabbits, dogs, monkeys, and humans. The aim of the present investigation was to study the complex of kinetic parameters of sarcolysine in rats in the case of various modes of administration and doses. The studies were conducted on noninbred white rats using [¹⁴C]sarcolysine. 12 refs., 2 figs., 2 tabs