[en] Currently, the best prospect for cure of haematological malignancy, particularly acute leukemia, is treatment with high dose chemoradiotherapy followed by allogeneic marrow transplantation. However, 15% of patients experience life-threatening or fatal nonhaematopoietic toxicity from standard preparative regimens of chemoradiotherapy combined with total body irradiation by external beam radiotherapy. The aim of this work was to develop a regimen which minimizes radiation toxicity through the use of selective internal beta radiotherapy by using samarium-153 EDTMP. Results of experiments conducted with rats is discussed

[en] Galactosyl neoglycoalbumin (NGA) is a synthetic ligand for the asialoglycoprotein receptor (hepatic binding protein) which resides exclusively on hepatocytes. Uptake of ^99mTc allows assessment of liver function based on receptor concentration as well as dynamic liver imaging. However, most biochemical studies on the uptake and hepatic mechanism of asiaglycoproteins have used ¹²⁵I labelled ligands. The authors have undertaken, therefore, a comparative study of NGA uptake and hepatic metabolism in the isolated perfused rat liver using both ^99mTc and ¹²⁵I radiolabelled NGA

[en] It is commonly accepted that the major limitation of tissue targeting with monoclonal antibodies (MAbs) resides in the blood-tissue barrier which is operative on high molecular weight (Mw) carrier molecules. To overcome this problem, multi-step approaches have recently been introduced which include bispecific antibodies or antibody conjugates together with low Mw radiolabeled species, the combination of both elements leading to a process of labeling in vivo

[en] Tumor cells in culture will take protein molecules such as albumin and ferritin and the intracellular transport of these proteins can be enhancement by basic polyamino acids and amino-dextrans. A similar enhancement may occur with the antitumor monoclonal antibodies (MAbs). The purpose of this study is to synthesize In-111 labeled MAb conjugated with electronegatively charged polymers and evaluate whether these polymers retain their immunoreactivity

[en] To better understand the biodistribution of lipophilic cationic technetium myocardial imaging agents, the chemical integrity in vitro and subcellular distribution of some technetium cations have been studied using technetium-99 NMR spectroscopy and electron probe X-ray microanalysis. Measurements were obtained on minced samples of a Langendorf perfused rat heart after injection of Tc(MIBI)₆⁺. Results show that the technetium complex is concentrated in mitochondria, probably as the free lipophilic cation

[en] New methods for the syntheses of carbon-11 labelled vinylic amides via the acid chlorides and of carbon-11 labelled allyl iodide via allyl alcohol have been developed. The vinylic amides are prepared by acid hydrolysis of carbon-11 labelled carbon dioxide followed by carboxylation of vinylmagnesium bromide of the resulting acrylic acid. The reaction of the subsequent acid chloride with amine yield the vinylic amides. Allyl alcohol is prepared by reduction of the acrylic acid magnesium salt with lithium aluminium hydride

[en] With the aim of developing multi-functional precursors labelled with short-lived radionuclides, the possibility of using carbon-11 labelled malonic ester derivatives in radiolabelling syntheses is being investigated. A number of biologically interesting molecules including alpha-methyl tyrosine, alpha-methyl phenylalanine, amphetamine as well as carboxylic acids and beta-keto esters have been labelled starting from these compounds

[en] A high-sensitivity method has been developed for the detection for carbon oxides in target materials used in the production of carbon-11 labelled carbon dioxide. The detector is a modified flame ionization detector (FID) which utilizes a nickel catalyst methanizer in the detector to convert carbon oxides to methane, a detectable species. The sensitivity of the modified detector is 10 ppb of carbon dioxide in 4 mL of sample volume. One disadvantage of the detector is the apparent introduction of carbon oxides into the sample stream from the aluminium body of the detector

[en] A new synthesis of the radioconjugating agent tetrafluorophenyl-m-iodobenzoate has been developed, and new derivatives of tetrafluorophenyl-5-iodopentenoate have been synthesized. These compounds, labelled with radioactive iodine, have been conjugated to antibodies, and the tissue distribution determined

[en] Several new iodinated derivatives of diazepam have been synthesized and evaluated for diagnostic use with single photon emission computed tomography (SPECT). These iododiazepam (IDZ) compounds were evaluated for receptor affinity, in vitro saturation binding, and in vivo biodistribution in mice. These data indicated that the newly synthesized 2'-IDZ holds great potential for the SPECT study of benzodiazepine receptor