[en] This document presents the activities of the CENBG for the 1999 and 2000 years. The activities are arranged into 7 topics: 1) astro-particles, 2) high spins and big deformations, 3) fundamental interactions, 4) exotic nuclei, 5) the down end of the nuclear fuel cycle and ADS (accelerator driven system), 6) theoretical physics and 7) at the interface between physics and biology. Among a lot of achievements relevant to INIS we can note: -) the investigation of 2 new modes of decay: the bound internal conversion and the Pauli forbidden bound internal conversion, -) the progress made on the Nemo-3 experiment whose purpose is the possibility of detecting the neutrinoless double beta decay from the kinematics specificities of the 2 electrons released, -) the first observation of the doubly-magic nucleus Ni⁴⁸, -) the beta delayed proton and gamma -ray spectroscopy of Mg²¹ and Si²⁵ nuclei, -) the identification of the fundamental state of Li¹⁰, -) the measurement of the masses of nuclei close to N = Z line in the region A = 80, -) the measurement of the beta decay of Ga⁶² (T = 116 ms), and concerning ADS technology: -) the neutron capture cross-section of Th²³² has been measured in the energy range from 60 keV to 2 MeV, -) the determination of neutron induced fission cross-section of Pa²³³ in the fast neutron energy range from 0.5 to 10 MeV, and -) the measurement of isotopic distributions for all residual elements from Ti to Pb produced in the reaction 1 A.GeV Pb²⁰⁸ on proton. (A.C.)