[en] Syntheses of environmentally friendly amide derivatives for the selective separation of actinides were studied. As for the ligand, we have synthesized TODGA (N,N-Tetraoctyl diglycolamide), DHOA (N,N-Dihexyloctaneamide), and D2EHBA (N,N-Di(2-ethyl)hexylbutanamide) in high yield. The amide derivative was successfully prepared by chlorination followed by amination method in a good synthetic yield. The structures of all synthetic precursors and final products were confirmed by NMR, IR, and Mass spectrophotometer