[en] This book is part 1 of the proceedings of the symposium. 77 papers are presented in this volume, most of them in English or German. All papers contain abstracts in English, German and French. All papers pertain to the subject areas of the use of radiopharmaceuticals in diagnosis and therapy, most of them in human medicine, some papers deal with animal experiments. Each paper is treated separately for the INIS-Atomindex. (A.N.)

[en] This book is part 2 of the proceedings of the symposium (part 1 is described in INIS-Atomindex 17/11). 1 lecture, 5 free presentations, 26 free paper sessions, 5 round table sessions and all the discussion remarks for the lectures of pt. 1 and pt. 2 are presented in this volume, most of them in English or German, some in French. All papers contain abstracts in English, German and French. All papers pertain to the subject areas of the use of radiopharmaceuticals in diagnosis and therapy, most of them in human medicine, some papers deal with animal experiments. Each paper is treated separately for this INIS-Atomindex. (A.N.)

[en] This book is part 1 of the proceedings of the symposium. Part 2 will be published later. 59 papers are presented in this volume, most of them in English or German. All papers contain abstracts in English, German and French. All papers pertain to the subject areas of the use of radiopharmaceuticals in diagnosis and therapy, most of them in human medicine, some papers deal with animal experiments. (A.N.)

[en] This book is part 2 of the proceedings of the symposium. 36 papers are presented in this volume, most of them in English or German. All papers contain abstracts in English, German and French. All papers pertain to the subject areas of the use of radiopharmaceuticals in diagnosis and therapy, most of them in human medicine, some papers deal with animal experiments. Each paper is treated separately for the INIS-Atomindex. Additionally there are protocols of several discussions contained in this volume. A list of chairmen, a particiants list, a list of exhibitors, a keyword index and an author index in this volume give an overview of the whole conference. (A.N.)

[en] 131-I labelled -amino-(4-hydroxybenzylidene)diphsphonate (131-I-pHOBDPNH₂) has been examined with SD rats for its osteotropic and other biokinetical characteristics. 131-I-pHOBDPNH₂ proved to have a high bone affinity, a fast blood clearance, and a rapid excretion through the kidneys. Depending on the age and pathophysiological state of the rats 40 - 60% of the injected activity were retained in the bone tissue after 24 h. The biological half life varied between 46 and 111 days. A scintigram of a patient is given as an example of the remarkable affinity to bone lesions. Pain relief could also be observed in one case. 131-I-pHOBDPNH₂ is therefore suggested as a radiotherapeutical for the palliative treatment of pain syndromes often accompanied with disseminated bone metastases. (Author)

[en] Using the reagents of the AMERLEX FT4 RIA Kit by AMERSHAM/BUCHLER, we developed a method for determining FT4 in whole blood on filter paper, which is suitable for automation and furnishes well reproducible results in no more than 90 minutes. During routine screening examinations for hypothyroidism TSH and FT4 were assayed in 6.500 newborns. In about 97% of all clinically normal newborns the call-back rate for FT4 assays is not higher than on TSH assaying (0.15%). The sensitivity and specificity of identifying hypothyroidism is apparently no worse than the diagnostic validity of TSH assays. FT4 assays offer additional diagnostic information on cerebral thyroid dysfunction and extrathyroid alterations of thyroid hormone metabolism. In diseased children at intensive care units repeat FT4 assays are suggestive prognostically. In newborns at a gestational age of less than 32 weeks and in diseased infants at intensive care units additional TSH assays are necessary if FT4 levels are reduced to differentiate between hypothyroxinemia and primary hypothyroidism. Provided our preliminary results are confirmed in larger series, FT4 assays can be recommended as a first step in the screening program for hypothyroidism. If FT4 levels are low, TSH can be determined in one and the same sample on the same day. As assays could be simplified and done more rapidly without any loss of diagnostic quality, considerable practical advantages could be gained. (Author)

[en] In patients undergoing surgical intensive care, who were not known to have any prior endocrine disease, testosterone and, in some instances, LH and FSH plasma levels were found to be reduced. Assays were therefore extended to other hormones. We examined 10 patients aged between 55 and 75 years who did not receive any hormonal treatment and were admitted to an intensive care unit postoperatively for peritonitis, acute respiratory insufficiency, acute renal insufficiency as welll as hemorrhagic or endotoxic shock. Basal plasma levels of prolactin, LH, FSH, testosterone, adrostenedione, dehydroepiandrosterone (DHEA), total estrogen, 17-β-estradiol, progesterone and 17-hydroxyprogesterone were assayed radioimmunologically. It was of interest to note that plasma testosterone levels were reduced in all patients. In addition, prolactin and DHEA were lower than normal in 2, while FSH, androstenedione and 17-β-estradiol were diminshed in one. In 2 patients androstenedione, 17-β-estradiol and 17-hydroxyprogesterone were increased, and in 1 patient either prolactin, FSH, DHEA or progesterone were higher than normal. All females showed elevated plasma prolactin, 17-β-estradiol and progesterone levels as well as reduced LH and FSH concentration. 4 patients had high testosterone and 2 elevated androstenedione and 17-hydroxyprogesterone levels. DHEA was lower than normal in 3 cases. Radioimmunological data suggest that prolactin, gonadotropin, androgen, estrogen or gestagen secretetion may be impaired in patients undergoing postoperative intensive care. (Autrhor)

[en] Radionuclide ventriculography is used to measure left ventricular ejection fraction (LVEF), end diastolic volume (LVEDV), and wall motion, and abnormal changes induced by isometric exercise are taken to signify the presence of left ventricular disease. This study investigates the reproducibility of the above measurements and challenges the assumption that isometric exercise is an adequate stress in the detection of coronary artery disease. In 15 subjects the reproducibility of sequential measurements was: LVEF +- 2.0 (SD 1.9) units, LVED +- 5.6 (SD 3.0)%, and subsequently only changes greater than 2 standard deviations from these means were considered significant. Isometric exercise induced significant LVEF in only 14 of 33 normal subjects, and 22 of 38 with coronary artery disease, and significant LVEDV changes in 16 normals and 19 with coronary artery disease. The magnitude and direction of changes that did occur were similar in the 2 groups and thus could not reliably separate them. Combining changes in LVEF and LVEDV did not increase sensitivity. 12 of the 38 with coronary artery disease, but non of the normal subjects, developed new wall motion abnormalities as judged by phase and amplitude images. It is concluded that changes in LVEF and LVEDV produced by isometric exercise are too small and variable for the test to be useful in the distinction of normals from those with coronary artery disease. The development of new wall motion abnormalities is however specific for the presence of disease. (Author)

[en] From 1972 to 1981 350 patients with malignant melanoma of the lower extremity underwent unilateral or bilateral endolymphatic radionuclide therapy after generous excision of the primary tumor. Unilateral treatment consisted in 0.5 mCi 131-I-triolein and 5 mCi 32-P-tri-n-octyl-phosphate administered as radioactively labeled Lipiodol UF, and X-ray contrast. For bilateral treatment 0.5 mCi 131-I and 2 mCi 32-P were applied in 3.5 ml of Lipiodol UF on each side. Applications, dosimetry and follow-ups were standardized. High-dosage intralymphatic radiotherapy serves the purpose of destroying 'micrometastases' which must be expected to be present in 25 to 38% of clinically normal lymph nodes even in stage I malignant melanoma. Treatment with a radioactively labelled radiopaque substance simultaneously offers diagnostic information. As the penetration of 32-P beta emissions is limited, adequate treatment is confined to metastases of less than 4 mm in size. If lymphography shows larger metastases, lymphadenectomy is inevitable. In a first series of 160 patients with stage I disease the 5-year-survival rate was 72%. Data are compared with those of other treatment modalities employed in malignant melanoma, e.g. lymphadenectomy, immunotherapy and isolated limb perfusion with cytostatics. (Author)

[en] The products of 99m-TcO₄^- reaction with dmpe 2 HCl were investigated at different reaction conditions. Four compounds, TcCl₂dmpe₂⁺ (II), Tc0₂dmpe₂⁺ (III), Tcdmpe₃⁺⁺ (IV) and a neutral or weakly cationic species were identified. II, III, and IV accumulate in the rat myocardium but also in different glands and in the periosteum of the bones. Only II is rapidly cleared from the blood. 150 min p.i. a good delineation of the pig heart was obtained with clear-cut separation of the myocardium and the blood pool. (Author)