Selenium metabolism in rats after administration of toxic doses of selenite
AbstractAbstract
[en] The organ concentration, excretion and excreted forms of selenium were studied in young and adult rats after a single subcutaneous injection of a sublethal dose of 75Se-selenite. In the young, about a 10-fold higher concentration of 75Se in the blood, liver kidneys and heart was found at all the experimental intervals studied (1 to 7 days). The highest 75Se concentration in the young was in the liver while in the adults it was found in the kidneys. The spectrum of radioselenium metabolites in the urine was similar in both groups. However, the main product excreted by young rats was 75Se-glutathione selenotrisulfide and an unidentified neutral substance while it was the trimethylselenonium ion in the adults. Ontogenetic differences in the selenium metabolism could be one of the factors underlying the differences in the response of the young and the adult rats to toxic doses of selenite. (author). 2 tabs., 9 refs
Primary Subject
Record Type
Journal Article
Journal
Country of publication
Descriptors (DEI)
Descriptors (DEC)
ANIMALS, BETA DECAY RADIOISOTOPES, DAYS LIVING RADIOISOTOPES, ELECTRON CAPTURE RADIOISOTOPES, ELEMENTS, EVEN-ODD NUCLEI, INTERMEDIATE MASS NUCLEI, ISOTOPE APPLICATIONS, ISOTOPES, MAMMALS, NUCLEI, OXYGEN COMPOUNDS, RADIOISOTOPES, RODENTS, SELENIUM COMPOUNDS, SELENIUM ISOTOPES, SEMIMETALS, VERTEBRATES
Reference NumberReference Number
INIS VolumeINIS Volume
INIS IssueINIS Issue