Nucleophilic substitution at cyclic sulphamates - routes to NCA [18F]fluoro-analogues of MK 801
AbstractAbstract
[en] Nucleophilic substitution by no-carrier added (NCA) [18F]fluoride at cyclic sulphamates provides an efficient route to NCA [18F]fluoro-analogues of the potent N-Methyl-D-aspartate (NMDA) receptor antagonist, MK 801. Thus chemically and radiochemically pure NCA 5-[18F]fluoromethyl- and 5-β-[18F]fluoroethyl-10,11-dihydro-5H-dibenzo[a, d]cyclohepten-5,10-imine can be prepared for i.v. injection in 25-30% radiochemical yield (decay-corrected) respectively, from cyclotron-produced [18F]fluoride in 2.5 h. (author)
Source
British Institute of Radiology meeting; London (UK); Nov 1987
Record Type
Journal Article
Literature Type
Conference
Journal
Applied Radiation and Isotopes; CODEN ARISE; v. 40(4); p. 325-328
Country of publication
Descriptors (DEI)
Descriptors (DEC)
BETA DECAY RADIOISOTOPES, BETA-PLUS DECAY RADIOISOTOPES, DRUGS, FLUORINE ISOTOPES, HOURS LIVING RADIOISOTOPES, INJECTION, INTAKE, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, LABELLED COMPOUNDS, LIGHT NUCLEI, MATERIALS, NUCLEI, ODD-ODD NUCLEI, ORGANIC COMPOUNDS, ORGANIC NITROGEN COMPOUNDS, RADIOACTIVE MATERIALS, RADIOISOTOPES, SYNTHESIS
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