Synthesis and preliminary animal studies of [131I]iodotropapride: A cerebral dopamine D2 receptor ligand
Cantineau, R.; Damhaut, P.; Plenevaux, A.; Lemaire, C.; Guillaume, M.
Eighth international symposium on radiopharmaceutical chemistry. Abstracts: Final report1990
Eighth international symposium on radiopharmaceutical chemistry. Abstracts: Final report1990
AbstractAbstract
[en] The authors have developed a new iodinated radioligand: iodine-131 labelled tropapide. Tropapride, iodotropapride, and bromotropapride are substituted benzamide antagonists which have shown high affinity and selectivity to dopamine receptors. The iodine labelled compound was synthesized by nucleophilic substitution on the corresponding brominated analog. Preliminary animal studies were conducted to evaluate the binding properties of [131I]iodotropapride as an in vivo dopaminergic tracer. Biodistribution studies in rats are discussed
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Eckelman, W.C.; Squibb (E.R.) and Sons, Inc., New Brunswick, NJ (United States). Squibb Inst. for Medical Research; 458 p; 1990; p. 368-369; 8. international symposium on radiopharmaceutical chemistry; Princeton, NJ (United States); 24-29 Jun 1990; CONF-9006363--ABSTS; John Wiley and Sons Ltd., 605 Third Avenue, New York, NY 10158
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Report
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Conference
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Descriptors (DEI)
ABSORPTION SPECTROSCOPY, AMIDES, AUTONOMIC NERVOUS SYSTEM AGENT, CEREBRUM, CHEMICAL PREPARATION, DOPAMINE, IN VITRO, IN VIVO, IODINE 131, LABELLING, LIGANDS, LIQUID COLUMN CHROMATOGRAPHY, MOLECULAR STRUCTURE, RADIOPHARMACEUTICALS, RATS, RECEPTORS, SINGLE PHOTON ECT, THYROID, TISSUE DISTRIBUTION, UPTAKE
Descriptors (DEC)
AMINES, ANIMALS, AROMATICS, BETA DECAY RADIOISOTOPES, BETA-MINUS DECAY RADIOISOTOPES, BODY, BRAIN, CARDIOTONICS, CARDIOVASCULAR AGENTS, CENTRAL NERVOUS SYSTEM, CHROMATOGRAPHY, COMPUTERIZED TOMOGRAPHY, DAYS LIVING RADIOISOTOPES, DISTRIBUTION, DRUGS, EMISSION COMPUTED TOMOGRAPHY, ENDOCRINE GLANDS, GLANDS, HYDROXY COMPOUNDS, INTERMEDIATE MASS NUCLEI, IODINE ISOTOPES, ISOTOPES, LABELLED COMPOUNDS, MAMMALS, MATERIALS, NERVOUS SYSTEM, NEUROREGULATORS, NUCLEI, ODD-EVEN NUCLEI, ORGANIC COMPOUNDS, ORGANIC NITROGEN COMPOUNDS, ORGANS, PHENOLS, POLYPHENOLS, RADIOACTIVE MATERIALS, RADIOISOTOPES, RODENTS, SEPARATION PROCESSES, SPECTROSCOPY, SYMPATHOMIMETICS, SYNTHESIS, TOMOGRAPHY, VERTEBRATES
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