Postoperative hypofractionated radiotherapy and conventionally fractionated radiotherapy in malignant astrocytomas (grade III)
AbstractAbstract
[en] A preliminary report on a randomized trial. Sixty-nine patients with histologically proven malignant astrocytoma received postoperative radiotherapy. Patients were randomized to two treatment arms: Hypofractionated Radiotherapy (HR) and Conventionally Fractionated Radiotherapy (CFR). In the CFR group (32 patients) the whole brain was irradiated to the total dose of 50 Gy in 25 fractions over 5 weeks, than a 10 Gy ''boost'' in five fractions was delivered to the site of primary lesion in 5 days. In HR group (37 patients) there were three courses of irradiation separated with a 1-month interval. In each of the two first series the patients received 20 Gy in five fractions in 5 days to the whole brain, and in the third course, 20 Gy ''boost'' in 5 days was delivered as in the CFR regimen. The tolerance of the treatment was good in both groups. Actuarial survival rates at 2 and 5 years were 18% and 4% respectively for patients treated with HR, and they were 19% and 4% for CFR group. (author). 24 refs
Original Title
Irradiation postoperatoire conventionnelle et hypofractionnee des astrocytomes malins de grade III. Resultats preliminaires d'un essai prospectif randomise
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