Lipiodol-cisplatin embolisation in hepatocellular carcinoma. Radiological technique and evaluation
AbstractAbstract
[en] In a 1-year period, 14 patients with inoperable, biopsy-proven hepatocellular carcinoma (HCC) underwent 18 superselective catheterisations of the proper hepatic artery with combined injection of Cisplatin and Lipiodol. According to Okuda et al. [1], patients were classified into clinical Stages I (2), II (7) and III (5). All 5 Stage III patients died during follow-up. Distal superselective catheterisation of the proper hepatic artery, in order to avoid Lipiodol embolism to the gastroduodenal, gastric or other anastomotic arteries was possible with conventional diagnostic catheters (5 cases) or, an easy-to-use and inexpensive coaxial catheterisation system (13 cases). Radiological follow-up was by means of computed tomography (CT) 24 h and 6 weeks after chemoembolisation. Further CT studies were performed depending on the patient's progress. Twelve patients had CT follow-up over at least 6 weeks. Hypervascular hepatocellular carcinomas tend to diminish in volume, especially those which retain Lipiodol after 6 weeks, and survival after intra-arterial chemotherapy is shorter in patients with hypovascular tumours which do not retain Lipiodol. (orig.)
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ANIMALS, BLOOD VESSELS, BODY, CARDIOVASCULAR SYSTEM, CONTRAST MEDIA, DIAGNOSTIC TECHNIQUES, DIGESTIVE SYSTEM, DISEASES, GLANDS, MAMMALS, MAN, MEDICINE, NEOPLASMS, OILS, ORGANIC COMPOUNDS, ORGANIC HALOGEN COMPOUNDS, ORGANIC IODINE COMPOUNDS, ORGANS, OTHER ORGANIC COMPOUNDS, PRIMATES, TOMOGRAPHY, VERTEBRATES
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