Enhancement of protective action of radioprotector
Dobric, S.; Milovanovic, S.
Proceedings of the XVIII. Yugoslav symposium on radiation protection, Yugoslav Radiological Protection Association, Belgrade (Yugoslavia); Institute of Nuclear Sciences VINCA, Belgrade (Yugoslavia)1995
Proceedings of the XVIII. Yugoslav symposium on radiation protection, Yugoslav Radiological Protection Association, Belgrade (Yugoslavia); Institute of Nuclear Sciences VINCA, Belgrade (Yugoslavia)1995
AbstractAbstract
[en] The efficacy of radioprotector WR-2721 (300 mg/kg ip, 20 min before irradiation), alone or in combination with an extract of Ginkgo biloba (TeboninR) (17.5 mg/kg ip, 20 min before, and then 1 hr and 24 hr after irradiation), an extract of thymus (ThymolipR) (10 mg/kg sc, 24 hr before and 15 min after irradiation), herbal mitogen agrostemin (0.1 mg/kg ip. 24 before and immediately after irradiation) and calcium antagonist verapamil (1 mg/kg ip, immediately before irradiation), was studied in adult male Wistar rats irradiated by 9 Gy and 12 Gy of X-rays. It was established that above mentioned compounds, except wr-2721, failed to protect irradiated animals. Given in combination with WR-2721 only agrostemin and verapamil enhanced the efficacy of the protector. The combination with verapamil was more effective providing protection even in supralethal irradiated rats. (author)
Original Title
Mogucnosti potenciranja zastitnog dejstva radioprotektora WR-2721
Primary Subject
Source
Kovacevic, M. (ed.) (Institut za Nuklearne nauke VINCA, Belgrade (Yugoslavia)); 392 p; ISBN 86-80055-70-0; ; 1995; p. 359-362; Institut za Nuklearne nauke VINCA; Belgrade (Yugoslavia); 18. Yugoslav symposium on radiation protection; XVIII Jugoslovenski simpozijum za zastitu od zracenja; Becici (Yugoslavia); 24-26 May 1995
Record Type
Book
Literature Type
Conference
Country of publication
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Descriptors (DEC)
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