[en] Objective: To evaluate the diagnostic value of SPECT rCBF imaging in examining patients with olivopontocerebellar atrophy (OPCA). Methods: SPECT rCBF imaging and MRI were performed on 20 patients with OPCA. All the results of two modalities were compared with each other. Results: Hypo-perfusions of brain were identified in patients with OPCA, especially in cerebellum, brain stem and basal ganglia, and in cerebral lobes in certain cases as well. Compared with MRI, SPECT showed more extensive foci. The positive rates in SPECT and MRI were 95% and 75% respectively. Conclusions: SPECT provides a new method for the diagnosis of OPCA. SPECT rCBF imaging is a more sensitive and effective method for OPCA lesion localization comparing with MRI. A combination of these two methods (SPECT and MRI) will improve the positive rate and accuracy for the diagnosis of OPCA