[en] The 10 MW high temperature gas cooled reactor (HTR-10) was built at Institute of Nuclear Energy Technology, Tsinghua University, and the first criticality was attained in Dec. 2000. The high temperature gas cooled reactor physics simulation code VSOP was used for the prediction of the fuel loading for HTR-10 first criticality. The number of fuel element and graphite element was predicted to provide reference for the first criticality experiment. The prediction calculations toke into account the factors including the double heterogeneity of the fuel element, buckling feedback for the spectrum calculation, the effect of the mixture of the graphite and the fuel element, and the correction of the diffusion coefficients near the upper cavity based on the transport theory. The effects of impurities in the fuel and the graphite element in the core and those in the reflector graphite on the reactivity of the reactor were considered in detail. The first criticality experiment showed that the predicted values and the experiment results were in good agreement with little relative error less than 1%, which means the prediction was successful