[en] With regard to the ISOL technique, the dependence of intermediate mass (80-160A) production on target and proton beam features has been investigated by means of hadronic transport Monte Carlo codes. The analysis of the target material (mechanism of production), dimensions (length and width) and composition as well as the proton beam energy has shown that in principle, regardless of technological difficulties, the production of neutron-rich isotopes of intermediate mass (80-160 A) can be successfully achieved with proton beams of low-medium energy into uranium thick targets. The power density in uranium targets bombarded by low-medium energy protons has been analyzed too