[en] The LISE code is intended to simulate medium-energy and high-energy fragment separators with electrostatic and/or magnetic selections. It is based on first-order optics and transport integral convolution techniques. Fragment separators such as LISE3, SISSI/LISE3 and SPEG at GANIL, FRS at GSI, COMBAS and ACCULINA at Dubna, A1200 and A1900 at NSCL, and RIPS at RIKEN are based on the separation of projectile-like fragments, and can be easily simulated via optical configuration files. The reaction mechanism assumed in this program is projectile fragmentation, suitable to simulate experiments at beam energies above 30 A MeV. However, built-in tools such as the physical calculator, nucleus database utilities, relativistic reaction kinematics calculations and beam optics transport calculations make it a very useful tool below this energy limit as well. The program can therefore be used for forecasting and tuning experiments using heavy-ion beams with energies ranging from 10 keV up to a few GeV per nucleon