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In vitro evaluation of N-(fluoro)Isopropyl norephedrine as potential cardiac imaging agents for PET

Groot, Tjibbe J. de; Buitenhuis, Corine K.M.; Rutgers, Marja; Waarde, Aren van; Visser, Gerben M.; Smets, Lou A.; Brodde, Otto-Erich; Vaalburg, Willem1996

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AbstractAbstract

[en] N-Isopropylnorephedrine (INE) and N-fluoroisopropylnorephedrine (FINE) were found to have a poor affinity for either β-adrenoceptors and the norepinephrine carrier protein. The low affinity of both compounds for Uptake-1 is probably due to the introduction of a bulky substituent on the nitrogen atom. It is concluded that INE and FINE cannot be used for cardiac imaging with PET

Primary Subject

RADIOLOGY AND NUCLEAR MEDICINE (S62)

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Record Type

Journal Article

Journal

Nuclear Medicine and Biology; ISSN 0969-8051;