Automated synthesis of 3'-Deoxy-3'-Fluorothymidine as metabolize imaging agent
AbstractAbstract
[en] 3'-Deoxy-3'-Fluorothymidine (18F-FLT) is synthesized by 'BAThy' method at Tracerlab FXf-N system. By using 5'-O-benzoyl-2,3-anhydro-thymidine (BAThy) as the precursor, 18F-FLT is obtained by two step reactions, including the nucleophilic fluoration and hydrolysis. The synthesis can be completed about 50 min. The radiochemical yield and radiochemical purity are about 10% and 95%, respectively. The procedure is guide simple and automated synthesis. (authors)
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2 figs., 5 refs.
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Journal Article
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Journal of Nuclear and Radiochemistry; ISSN 0253-9950; ; v. 28(3); p. 174-177
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Descriptors (DEC)
AZINES, BETA DECAY RADIOISOTOPES, BETA-PLUS DECAY RADIOISOTOPES, CHEMICAL REACTIONS, DECOMPOSITION, DRUGS, FLUORINE ISOTOPES, HALOGENATION, HETEROCYCLIC COMPOUNDS, HOURS LIVING RADIOISOTOPES, ISOMERIC TRANSITION ISOTOPES, ISOTOPES, LABELLED COMPOUNDS, LIGHT NUCLEI, LYSIS, MATERIALS, NANOSECONDS LIVING RADIOISOTOPES, NUCLEI, NUCLEOSIDES, NUCLEOTIDES, ODD-ODD NUCLEI, ORGANIC COMPOUNDS, ORGANIC HALOGEN COMPOUNDS, ORGANIC NITROGEN COMPOUNDS, PYRIMIDINES, RADIOACTIVE MATERIALS, RADIOISOTOPES, RIBOSIDES, SOLVOLYSIS
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