[en] Objective: To study the possible protective effect of combined captopril and lovastatin treatment on kidney function through lowering of serum TNF-α levels in rat models of adriamycin nephropathy. Methods: Male rat models of nephropathy (24h urinary protein > 100rog, n = 120) were successfully prepared with intravenous injection of adriamycin (5.5rog/kg). The models were divided into 4 equal numbered groups (n=30) (1) not specifically treated (2) treated with captopril (30mg/kg/d) garage (3) treated with lovastatin (15 mg/kg/d) gavage (4) treated with captopril and lovastatin combined at the above dosage. Serum TNF-α, albumin, cholesterol and triglyceride levels and 24h urine protein contents were determined in 6 models from each group at 2,4 and 6 weeks. Results: The serum TNF-α, cholesterol and triglyceride levels were significantly lower in the models of 3 treated groups than those in untreated models, especially with the combined treated ones. The 24h urinary protein excretion was reduced with elevated serum albumin levels. Conclusion: Combined administration of captopril and lovastatin resulted in the lowest serum TNF-α levels with most favorable protection of renal function in rat models of nephropathy induced by adriamycin. (authors)