[en] Objective was to investigate the relationship between survivingexpression and invasiveness of pituitary adenoma. A total of 66 patients, onwhom transphenoidal surgery had been performed between July 2006 and March2008, were enrolled in our study at the Department of Neurosurgery inShandong Provincial Hospital and Jinan Central Hospital, Shandong, P. R.China. All patients were divided into the invasion group (n=39) and thenon-invasion group (n=27) by assessment of preoperative MRI andintraoperative inspection. Survivin expression was determined byimmunohistochemistry. Statistical analysis of surviving expression betweenthe 2 sample groups was accomplished using the chi-square test. Survivin wasexpressed in 46 (69.7%) of the investigated pituitary adenomas. For invasivepituitary adenoma, surviving staining was positive in 35 (89.7%), only 11(40.7%) specimens were positive in noninvasive tumors. The chi-square testdemonstrated a statistically significant difference in surviving expressionbetween invasive and noninvasive pituitary adenoma (X2=14.30, p=0.0002).Survivin was highly associated with invasive pituitary adenoma, it is likelyto serve as a useful tool for confirmation of invasive pituitary adenoma andthe gene could be an effective target for pituitary adenoma gene therapy.(author)