[en] A general control system for the Materials and Life Science Experimental Facility (MLF-GCS) at J-PARC has an advanced and independent system for control of the mercury target, including a circulation system with a large amount of mercury, three moderators with supercritical hydrogen, and cooling systems with radioactive water. Although the MLF-GCS is an independent system, it works closely with the accelerator and other facility control systems within J-PARC. The MLF-GCS consists of several subsystems of integral control and interlock, network, server, timing distribution systems, and personnel protection system (PPS). The design and construction of MLF-GCS has progressed for the first proton beam injection in 2008. After finishing the construction of most of the MLF-GCS subsystems, the commissioning on operation and control of the whole MLF has started step by step in 2007. During short period before the first beam injection, the trial operations, performance tests, and improvements of the MLF-GCS subsystems have been executed under restricted conditions. After the first beam injection in May 2008, the subsystems have been improved according to experience on the beam operations, the administrative structure for the MLF operation shift has been established, and the stable and efficient operations of the MLF-GCS has been realized. This paper reports on the commissioning on the MLF operation and control from April 2007 to March 2009. (author)