[en] Topical pilocarpine (1.0, 2.0 and 4.0 per cent) and 2.0 per cent pilocarpine plus 1.0 per cent epinephrine markedly increased conventional aqueous humour outflow, as measured by non-invasive tomography, in both normal beagles and beagles with inherited glaucoma. Pilocarpine in normal eyes increased the coefficient or outflow from 0.33 mu-l/min/mmHg (pre-drug) to 0.55 mu-l/min/mmHg (1.0 per cent), 0.57 mu-l/min/mmHg (2.0 per cent), and 0.61 mu-l/min/mmHg (4.0 per cent). In beagles with inherited glaucoma, topical pilocarpine increased the coefficient of outflow from 0.15 mu-l/min/mmHg (pre-drug) to 0.24 mu-l/min/mmHg (1.0 per cent), 0.21 mu-l/min/mmHg (2.0 per cent) and 0.38 mu-l/min/mmHg (4.0 per cent). The 2.0 per cent pilocarpine plus 1.0 per cent epinephrine solution in normal eyes increased the coefficient of outflow from 0.27 mu-l/min/mmHg to 0.36 mu-l/min/mmHg. In the glaucomatous eyes the 2 per cent pilocarpine pus 1 per cent epinephrine combination, increased the coefficient outflow from 0.20 mu-l/min/mmHg to 0.30 mu-l/min/mmHg