[en] The plasma focus device functions as a multi-radiation source by accelerating and compressing the plasma produced. Irradiation of bacteria with Malaysian Nuclear Agency-Plasma Focus has never been conducted. Thus, various operation parameters are unknown. This study aims to determine the feasibility of using certain types of tube and number of shots to conduct irradiation of bacteria. Two types of tubes were irradiated: microcentrifuge tubes (Axygen) 1.5 mL with snap cap and conical-bottom and microcentrifuge tubes (SSL) 2.0 mL with screw cap and skirted-bottom. Voltages of 11.5 kV was applied. Also, comparisons were made between tubes given 1 shot and 2 shots during the same irradiation session. All changes to colour and material of tubes were observed. Microcentrifuge tubes 1.5 mL with snap cap and conical-bottom were damaged more than microcentrifuge tubes 2.0 mL with screw cap and skirted-bottom. Durability of tubes will decrease with increasing number of plasma shots given. In conclusion, it was determined using microcentrifuge tubes 2.0 mL with screw cap and skirted-bottom and only 1 shot of plasma to be feasible for bacteria culture irradiation. Further studies will be conducted to support this preliminary study. (author)