[en] A single-stage reprocessing of the irradiated target on the basis of curium heavy isotopes is described. The target was irradiated in the SM-2 reactor with an integral flux of 3.5x10²² neutr/cm². The extraction and separation of transplutonium elements (TRE) were made in the lithium chloride-trioctyalammonium chloride system in an extraction-chromatographic mode. Extraction in the chloride medium was performed in the following order: Cm< Bk approximately Es< Cf, the separation factor for curium and californium being 7.5. No considerable separation of berkelium and einsteinium was observed, the curium yield in the process being 94.7% and californium yield 93%. By successively using several eluents with a varying concentration of lithium chloride the separation of structural materials( Tramex process), intergroup separation of actinoid and fission elements and also intragroup separation of TPE were made