Kode Chemoinformatics

We are pleased to read and share an interesting article by Marco Lucentini, Production Manager at SCAM Spa, and Francesca Sbolgi, Data Scientist at Kode, about the application of SpectralizeR, the #chemometric software by Kode, on SCAM's production line. Thanks to the integration of in-line spectroscopic measurements into an application allowing real-time data analysis and chemometric models' management, SCAM can now ensure the highest quality of every single product released to the market. Learn more in the article on AI4Business - Nextwork360

We're glad to share an interesting implementation of hashtag #AI LLM models in #bioinformatics research by Scuola Normale Superiore. The study conducted by Francesco Carli, under the supervision of Associate Professor of Scuola Normale Superiore Francesco Raimondi, leverages drug sensitivity of cancer cell lines (CCLs) as datasets to predict drug response using cell line transcriptomics, focusing on models’ interpretability and deployment on patients’ data. In this case, large language models (including #MixtralAI and #ChatGPT) are exploited to match drug to mechanisms of action (MOA)-related pathways. The models, in the end, allow predicting effective drugs for the patients of two highly lethal solid tumours, i.e., pancreatic cancer and glioblastoma. Congrats on this useful application of Data Science to real life, for the treatment of such aggressive diseases. Learn more: https://lnkd.in/dUWYUag9

𝐒𝐀𝐕𝐄 𝐓𝐇𝐄 𝐃𝐀𝐓𝐄 #ServiziaReteTOUR "𝗔𝗜 𝗮𝗻𝐝 𝗗𝗶𝗴𝗶𝘁𝗶𝘇𝗮𝘁𝗶𝗼𝗻 𝗶𝗻 𝗪𝗮𝘁𝗲𝗿 𝗨𝘁𝗶𝗹𝗶𝘁𝘆" 📆 𝟐𝟖 𝐞 𝟐𝟗 𝐦𝐚𝐠𝐠𝐢𝐨 𝟐𝟎𝟐𝟓 📍 presso il 𝐁𝐫𝐢𝐱𝐢𝐚 𝐅𝐨𝐫𝐮𝐦, 𝐁𝐫𝐞𝐬𝐜𝐢𝐚 EBWorld onfirms its participation in the #ServiziAReteTour2025 organized by Servizi a Rete, un network di 4Pixel in collaboration with A2A. This year, they will be joined by the Kode teams, to share their joint #AI-based solutions and services dedicated to the Water Utility sector. These solutions bring added value by enhancing infrastructure #operations management, anticipating critical issues, and optimizing operational processes. Don't miss out. Register now: 👇 🌐https://lnkd.in/dErrxdZh #WaterUtility #GIS #assetmanagement

The new issue of the Kode newsletter is just around the corner, so sign up now and find out about the tangible benefits of data science and what's new in the world of #AI for #manufacturing #assetmanagement #chemistry #sportsanalytics #mobility Subscribe now: https://lnkd.in/ddw_JeQC

⚛️ 𝑴𝒐𝒍𝒆𝒄𝒖𝒍𝒆 𝒊𝒏 𝒕𝒉𝒆 𝒔𝒑𝒐𝒕𝒍𝒊𝒈𝒉𝒕 ⚛️ 𝐍𝐞𝐰 𝐡𝐨𝐩𝐞 𝐟𝐨𝐫 𝐩𝐚𝐭𝐢𝐞𝐧𝐭𝐬 𝐰𝐢𝐭𝐡 ALK-positive locally advanced or metastatic non-small cell 𝐥𝐮𝐧𝐠 𝐜𝐚𝐧𝐜𝐞𝐫 (𝐍𝐒𝐂𝐋𝐂)! On December 18, 2024, the FDA approved Ensartinib for the treatment of adult patients facing this aggressive form of lung cancer. This month's issue by our #Chemoinformatician Nedra Mekni, PhD explores Ensartinib’s pivotal role as a cornerstone therapy in ALK-positive cancer care, delving into the science behind this compound, its molecular mechanisms, and its role in redefining treatment for ALK-positive cancers. Read the article at the link below #drugdesign #chemistry #biotechnology #chemoinformatics #lungcancer #cancer

Today Italy enforces the regulation implementing the European SUP (#SingleUsePlastics) directive to reduce non-biodegradable, single-use plastics. At Kode , we’ve always been strong advocates for sustainability at every level—whether in developing our software and data management systems, the projects we work on with our clients, or our everyday practices. In our offices and at our events, we promote the use of reusable cups and encourage a Green lifestyle. This means not only cutting down on waste but also raising awareness about mindful consumption of natural resources—like water, which is still too often wasted in many ways. Share this post and join us in raising awareness for a more sustainable world! #plastic #plasticfree #sustainability #zerowaste

Our Kode Chemoinformatics Business Unit is also wrapping up the year in a flurry of preparations for a new year full of exciting developments. These holidays will be a brief pause for us, too, as we look forward to seeing you all again soon and sharing all our news with you. Merry Christmas!

𝐓𝐡𝐞 𝐦𝐨𝐥𝐞𝐜𝐮𝐥𝐞 𝐨𝐟 𝐗𝐦𝐚𝐬 Several molecules contribute to the Christmas tree aroma. Much like the scent of the Christmas tree arises from a harmonious blend of molecules, our holidays are a joyful composition of intangible elements. This year, we wish you a Christmas filled with molecules of joy, serenity, love, and all the components you desire to create the perfect aroma for your celebrations. Merry Christmas! 𝓣𝓱𝓮 𝓬𝓱𝓮𝓶𝓲𝓼𝓽𝓻𝔂 𝓫𝓮𝓱𝓲𝓷𝓭 𝓽𝓱𝓮 𝓟𝓲𝓷𝓮'𝓼 𝓢𝓬𝓮𝓷𝓽 The festive scent of conifer trees is powered by natural compounds like Bornyl Acetate, Alpha-pinene, and Beta-pinene, found in conifers such as silver fir, Scots pine, and Norway spruce. Extracted from resins and needles through distillation, Bornyl Acetate provides a fresh, balsamic aroma, while Alpha- and Beta-pinene add sharp, piney, and woody notes.

📣 New project released: Kode and SCAM Spa a leading company in granular organo-mineral fertilisers, support eco-sustainability, by developing an #AI-based, real-time monitoring system for its production process guaranteeing the #quality of every single bag released to the market. SCAM's Organo-Mineral Fertilizers have been developed over the years with meticulous calibrations, aiming to create solutions suitable for sustainable and green agriculture. For this reason, careful monitoring of every product characteristic is essential to ensure product quality. The system, based on NIR probes, collects spectroscopic readings at two critical points in the production plant to monitor this fundamental aspect both during the process and in the final stage before commercialization (just before packaging). This ensures the quality of every single bag released to the market. The analysis system for spectral signals acquired by #NIR probes installed in production has been integrated into a custom software solution based on #SpectralzieR (software solution by Kode). The solution for SCAM includes all the operational features needed for their daily fertilizer production activities: from Historical Analysis to the #DriftPrevention system, and real-time in-line Monitoring of the moisture content, which enables SCAM Spa to ensure the quality of every single bag released to the market. Learn more: https://lnkd.in/dc9dAHWm

⚛ Molecule in the spotlight ⚛ In October 2024, the U.S. FDA approved VYALEV™, a major advancement in the treatment of advanced Parkinson's disease. While Vyalev does not directly target the underlying causes of Parkinson's disease, such as the aggregation of alpha-synuclein, it addresses the dopaminergic dysfunction that is central to the disease's motor symptoms. Read the article by our #Chemoinformatician Nedra Mekni, PhD and discover more about the Biopathology and evolution in Treatment for Parkinson's Disease. #drugdesign #chemistry #biotechnology #chemoinformatics #neurodegenerative #neurology